Assessment of plasma protein C activity in dogs with portosystemic shunt

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16810%2F23%3A43880995" target="_blank" >RIV/62157124:16810/23:43880995 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/23:00133639 RIV/62157124:16170/23:43880995

Výsledek na webu

<a href="https://actavet.vfu.cz/media/pdf/actavet_2023092030289.pdf" target="_blank" >https://actavet.vfu.cz/media/pdf/actavet_2023092030289.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb202392030289" target="_blank" >10.2754/avb202392030289</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Assessment of plasma protein C activity in dogs with portosystemic shunt

Popis výsledku v původním jazyce

Portosystemic shunt (PSS) is a vascular disease that can be treated by various surgical techniques. Current veterinary studies are evaluating new prognostic markers in dogs with PSS. This study aims at evaluating the prognostic value of plasma protein C activity in dogs (n = 34) with PSS treated surgically using an ameroid constrictor. Plasma protein C activity was measured in the following time periods: preoperatively (T1), 2 days after surgery (T2), 8 weeks after surgery (T3) and &gt; 6 months after surgery (T4). There was a significant increase in plasma protein C activity between T1/T2 and T3/T4 (P &lt; 0.001). There was no significant relationship between the plasma protein C activity and sex (P = 0.676), age (P = 0.172), breed (P = 0.573), type of clinical signs (neurological P = 0.993; gastrointestinal P = 0.924; urological P = 0.385) and type of portosystemic shunt (P = 0.516), except for dogs with a caval type of extrahepatic PSS termination that had significant lower plasma protein C activity values compared to dogs with a diaphragmatic type of extrahepatic PSS (P = 0.031). No significant relationship was found between plasma protein C activity and the probability of the dog’s death (P = 0.334) or the dog’s clinical outcome (P = 0.960). Although not a prognostic factor, protein C activity is a laboratory marker that is useful for the diagnosis of PSS in dogs and can also be helpful in the postoperative monitoring.

Název v anglickém jazyce

Assessment of plasma protein C activity in dogs with portosystemic shunt

Popis výsledku anglicky

Portosystemic shunt (PSS) is a vascular disease that can be treated by various surgical techniques. Current veterinary studies are evaluating new prognostic markers in dogs with PSS. This study aims at evaluating the prognostic value of plasma protein C activity in dogs (n = 34) with PSS treated surgically using an ameroid constrictor. Plasma protein C activity was measured in the following time periods: preoperatively (T1), 2 days after surgery (T2), 8 weeks after surgery (T3) and &gt; 6 months after surgery (T4). There was a significant increase in plasma protein C activity between T1/T2 and T3/T4 (P &lt; 0.001). There was no significant relationship between the plasma protein C activity and sex (P = 0.676), age (P = 0.172), breed (P = 0.573), type of clinical signs (neurological P = 0.993; gastrointestinal P = 0.924; urological P = 0.385) and type of portosystemic shunt (P = 0.516), except for dogs with a caval type of extrahepatic PSS termination that had significant lower plasma protein C activity values compared to dogs with a diaphragmatic type of extrahepatic PSS (P = 0.031). No significant relationship was found between plasma protein C activity and the probability of the dog’s death (P = 0.334) or the dog’s clinical outcome (P = 0.960). Although not a prognostic factor, protein C activity is a laboratory marker that is useful for the diagnosis of PSS in dogs and can also be helpful in the postoperative monitoring.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

1801-7576

Svazek periodika

92

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

13

Strana od-do

289-301

Kód UT WoS článku

001153359000009

EID výsledku v databázi Scopus

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