Kinetic parameters survey for manufacture of pralidoxime

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F15%3A50003725" target="_blank" >RIV/62690094:18450/15:50003725 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.11648/j.ajche.20150303.12" target="_blank" >http://dx.doi.org/10.11648/j.ajche.20150303.12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.11648/j.ajche.20150303.12" target="_blank" >10.11648/j.ajche.20150303.12</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Kinetic parameters survey for manufacture of pralidoxime

Popis výsledku v původním jazyce

Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three stepsfor the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.

Název v anglickém jazyce

Kinetic parameters survey for manufacture of pralidoxime

Popis výsledku anglicky

Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three stepsfor the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American journal of chemical engineering

ISSN

2330-8605

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

39-51

Kód UT WoS článku

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EID výsledku v databázi Scopus

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