Behavioral toxicity of nerve agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18460%2F20%3A50016768" target="_blank" >RIV/62690094:18460/20:50016768 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18470/20:50016768

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-819090-6.00033-7" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-819090-6.00033-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-819090-6.00033-7" target="_blank" >10.1016/B978-0-12-819090-6.00033-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Behavioral toxicity of nerve agents

Popis výsledku v původním jazyce

Behavioral changes in humans exposed to highly toxic organophosphorus (OP) compounds, called nerve agents, have been discussed in numerous reports. The incidence of behavioral effects is higher in individuals who have been severely exposed to nerve agents, but they may also occur in individuals who have received a low-level exposure below those producing convulsions and other severe clinical signs of toxicity. The behavioral effects usually start within a few hours and last from several days to several weeks or months. The most frequent symptoms include feelings of uneasiness, tenseness, and fatigue. Exposed individuals may be forgetful and generally display impaired memory and learning, poor comprehension, decreased ability to communicate, and occasional mild confusion. There are a few reports describing behavioral changes in subjects accidentally exposed to nerve agents. They reported sleep disturbance, mood changes, fatigue, jitteriness or tenseness, an inability to read with comprehension, difficulties with thinking and expression, forgetfulness, a feeling of being mentally slowed, depression, irritability, giddiness, poor performance in arithmetic tests, minor difficulties in orientation, and frightening dreams. It was observed that the complex of central nervous system (CNS) symptoms may not fully develop until 24 h after exposure. In addition, no correlations between the presence or severity of symptoms and the degree of acetylcholinesterase inhibition were seen. Most of the effects of exposure disappear within 3 days. It was concluded that not only severe but also mild intoxication of nerve agents may cause behavioral and psychological disturbances. In general, the behavioral effects have not been permanent but have lasted from weeks to several months, or possibly several years. Long-term behavioral effects after poisoning with nerve agents or organophosphorus insecticides have been reported (Karczmar, 1984; Levin and Rodnitzki, 1976; Loh et al., 2010). These reports are based on clinical observations, which are occasionally supported by psychological studies.

Název v anglickém jazyce

Behavioral toxicity of nerve agents

Popis výsledku anglicky

Behavioral changes in humans exposed to highly toxic organophosphorus (OP) compounds, called nerve agents, have been discussed in numerous reports. The incidence of behavioral effects is higher in individuals who have been severely exposed to nerve agents, but they may also occur in individuals who have received a low-level exposure below those producing convulsions and other severe clinical signs of toxicity. The behavioral effects usually start within a few hours and last from several days to several weeks or months. The most frequent symptoms include feelings of uneasiness, tenseness, and fatigue. Exposed individuals may be forgetful and generally display impaired memory and learning, poor comprehension, decreased ability to communicate, and occasional mild confusion. There are a few reports describing behavioral changes in subjects accidentally exposed to nerve agents. They reported sleep disturbance, mood changes, fatigue, jitteriness or tenseness, an inability to read with comprehension, difficulties with thinking and expression, forgetfulness, a feeling of being mentally slowed, depression, irritability, giddiness, poor performance in arithmetic tests, minor difficulties in orientation, and frightening dreams. It was observed that the complex of central nervous system (CNS) symptoms may not fully develop until 24 h after exposure. In addition, no correlations between the presence or severity of symptoms and the degree of acetylcholinesterase inhibition were seen. Most of the effects of exposure disappear within 3 days. It was concluded that not only severe but also mild intoxication of nerve agents may cause behavioral and psychological disturbances. In general, the behavioral effects have not been permanent but have lasted from weeks to several months, or possibly several years. Long-term behavioral effects after poisoning with nerve agents or organophosphorus insecticides have been reported (Karczmar, 1984; Levin and Rodnitzki, 1976; Loh et al., 2010). These reports are based on clinical observations, which are occasionally supported by psychological studies.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

50601 - Political science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of Toxicology of Chemical Warfare Agents

ISBN

978-0-12-819090-6

Počet stran výsledku

15

Strana od-do

499-513

Počet stran knihy

1318

Název nakladatele

Elsevier

Místo vydání

Oxford

Kód UT WoS kapitoly

—