Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F13%3A50001680" target="_blank" >RIV/62690094:18470/13:50001680 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.benthamscience.com/contents.php?in=108957&m=May&y=2013" target="_blank" >http://www.benthamscience.com/contents.php?in=108957&m=May&y=2013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/0929867311320160006" target="_blank" >10.2174/0929867311320160006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs

Popis výsledku v původním jazyce

K203 is an experimental bis-pyridinium mono-aldoxime type cholinesterase reactivator of potential use in organophosphate/organophosphonate poisoning. Pharmacokinetics of K203 were examined in Wistar rats and beagle dogs using ion-pair HPLC. Serum and cerebrospinal fluid concentrations of K203 were determined using ion-pair reversed-phase chromatography on octadecyl silica column. HPLC with ultraviolet detection was used for determination of serum concentration of K203 higher than 0.1 mu g/mL while its low concentrations in cerebrospinal fluid required electrochemical detection (0.015 through 4 mu g/mL range). In rats the serum levels of K203 followed zero order pharmacokinetics from 15 to 120 minutes post administration. Zero order pharmacokinetics wasalso observed in beagle dogs after low dose (15 mu mol/kg) of K203 administration. High dose administration (250 mu mol/kg) led to subsequent hindered elimination from both cerebrospinal fluid and serum.

Název v anglickém jazyce

Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs

Popis výsledku anglicky

K203 is an experimental bis-pyridinium mono-aldoxime type cholinesterase reactivator of potential use in organophosphate/organophosphonate poisoning. Pharmacokinetics of K203 were examined in Wistar rats and beagle dogs using ion-pair HPLC. Serum and cerebrospinal fluid concentrations of K203 were determined using ion-pair reversed-phase chromatography on octadecyl silica column. HPLC with ultraviolet detection was used for determination of serum concentration of K203 higher than 0.1 mu g/mL while its low concentrations in cerebrospinal fluid required electrochemical detection (0.015 through 4 mu g/mL range). In rats the serum levels of K203 followed zero order pharmacokinetics from 15 to 120 minutes post administration. Zero order pharmacokinetics wasalso observed in beagle dogs after low dose (15 mu mol/kg) of K203 administration. High dose administration (250 mu mol/kg) led to subsequent hindered elimination from both cerebrospinal fluid and serum.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current medicinal chemistry

ISSN

0929-8673

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

16

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

2137-2144

Kód UT WoS článku

000317662200006

EID výsledku v databázi Scopus

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