Dose?response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F13%3A%230001857" target="_blank" >RIV/00027014:_____/13:#0001857 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.vuzv.cz/sites/File/_privat/13088.pdf" target="_blank" >http://www.vuzv.cz/sites/File/_privat/13088.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carbpol.2013.05.044" target="_blank" >10.1016/j.carbpol.2013.05.044</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dose?response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats

Popis výsledku v původním jazyce

The dose?response efficiency and long-term effect of the hypocholesterolemic effect of octadecylpectinamide was examined in female rats fed diets containing cholesterol at 10 g/kg. In our first experiment, amidated pectin supplied at 20 g/kg, 40 g/kg and60 g/kg significantly decreased serum cholesterol from 3,32 mol/ml (control) to 1,23 mol/ml in a dose-dependent manner. In a second experiment, the hypocholesterolemic effect of amidated pectin supplied at 20 g/kg persisted after 3 months of feeding. Inboth experiments, the amidated pectin significantly decreased the concentrations of cholesterol in hepatic tissue and triacylglycerols in serum. The serum concentration of aspartate aminotransferase significantly increased in rats fed amidated pectin at60 g/kg for 4 weeks, and at 20 g/kg for 3 months. In onclusion, amidated pectin at a low dose and used for a period shorter than 3 months might be considered as an effective hypocholesterolemic and lipid-lowering agent that may substitut

Název v anglickém jazyce

Dose?response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats

Popis výsledku anglicky

The dose?response efficiency and long-term effect of the hypocholesterolemic effect of octadecylpectinamide was examined in female rats fed diets containing cholesterol at 10 g/kg. In our first experiment, amidated pectin supplied at 20 g/kg, 40 g/kg and60 g/kg significantly decreased serum cholesterol from 3,32 mol/ml (control) to 1,23 mol/ml in a dose-dependent manner. In a second experiment, the hypocholesterolemic effect of amidated pectin supplied at 20 g/kg persisted after 3 months of feeding. Inboth experiments, the amidated pectin significantly decreased the concentrations of cholesterol in hepatic tissue and triacylglycerols in serum. The serum concentration of aspartate aminotransferase significantly increased in rats fed amidated pectin at60 g/kg for 4 weeks, and at 20 g/kg for 3 months. In onclusion, amidated pectin at a low dose and used for a period shorter than 3 months might be considered as an effective hypocholesterolemic and lipid-lowering agent that may substitut

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GH - Výživa hospodářských zvířat

OECD FORD obor

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Projekt

<a href="/cs/project/GAP503%2F11%2F2479" target="_blank" >GAP503/11/2479: Inhibice intestinální absorpce sterolů hydrofobně modifikovanými polysacharidy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Carbohydrate Polymers 

ISSN

0144-8617

e-ISSN

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Svazek periodika

97

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

772-775

Kód UT WoS článku

000323805000072

EID výsledku v databázi Scopus

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