Mycotoxins as human carcinogens-the IARC Monographs classification

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F17%3A50005520" target="_blank" >RIV/62690094:18470/17:50005520 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/75010330:_____/17:00011688

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs12550-016-0265-7" target="_blank" >http://link.springer.com/article/10.1007%2Fs12550-016-0265-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12550-016-0265-7" target="_blank" >10.1007/s12550-016-0265-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mycotoxins as human carcinogens-the IARC Monographs classification

Popis výsledku v původním jazyce

Humans are constantly exposed to mycotoxins (e.g. aflatoxins, ochratoxins), mainly via food intake of plant and animal origin. The health risks stemming from mycotoxins may result from their toxicity, in particular their carcinogenicity. In order to prevent these risks, the International Agency for Research on Cancer (IARC) in Lyon (France)-through its IARC Monographs programme-has performed the carcinogenic hazard assessment of some mycotoxins in humans, on the basis of epidemiological data, studies of cancer in experimental animals and mechanistic studies. The present article summarizes the carcinogenic hazard assessments of those mycotoxins, especially aflatoxins (aflatoxin B-1, B-2, G(1), G(2) and M-1), fumonisins (fumonisin B-1 and B-2) and ochratoxin A (OTA). New information regarding the genotoxicity of OTA (formation of OTA-DNA adducts), the role of OTA in oxidative stress and the identification of epigenetic factors involved in OTA carcinogenesis-should they indeed provide strong evidence that OTA carcinogenicity is mediated by a mechanism that also operates in humans-could lead to the reclassification of OTA.

Název v anglickém jazyce

Mycotoxins as human carcinogens-the IARC Monographs classification

Popis výsledku anglicky

Humans are constantly exposed to mycotoxins (e.g. aflatoxins, ochratoxins), mainly via food intake of plant and animal origin. The health risks stemming from mycotoxins may result from their toxicity, in particular their carcinogenicity. In order to prevent these risks, the International Agency for Research on Cancer (IARC) in Lyon (France)-through its IARC Monographs programme-has performed the carcinogenic hazard assessment of some mycotoxins in humans, on the basis of epidemiological data, studies of cancer in experimental animals and mechanistic studies. The present article summarizes the carcinogenic hazard assessments of those mycotoxins, especially aflatoxins (aflatoxin B-1, B-2, G(1), G(2) and M-1), fumonisins (fumonisin B-1 and B-2) and ochratoxin A (OTA). New information regarding the genotoxicity of OTA (formation of OTA-DNA adducts), the role of OTA in oxidative stress and the identification of epigenetic factors involved in OTA carcinogenesis-should they indeed provide strong evidence that OTA carcinogenicity is mediated by a mechanism that also operates in humans-could lead to the reclassification of OTA.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mycotoxin research

ISSN

0178-7888

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

65-73

Kód UT WoS článku

000392347800007

EID výsledku v databázi Scopus

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