Analyses of biomarkers of exposure to nephrotoxic mycotoxins in a cohort of patients with renal tumours

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50016040" target="_blank" >RIV/62690094:18470/19:50016040 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/19:10399781 RIV/00179906:_____/19:10399781 RIV/75010330:_____/19:00012695

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s12550-019-00365-9" target="_blank" >https://link.springer.com/article/10.1007/s12550-019-00365-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12550-019-00365-9" target="_blank" >10.1007/s12550-019-00365-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analyses of biomarkers of exposure to nephrotoxic mycotoxins in a cohort of patients with renal tumours

Popis výsledku v původním jazyce

The Czech Republic occupies the first place in the world in the frequency of renal and other urinary tract tumours, but their aetiology is unknown. To explore whether carcinogenic and nephrotoxic mycotoxins may contribute to kidney diseases in the Czech population, biomarkers of ochratoxin A (OTA) and citrinin (CIT) exposure were determined in biological specimens from a cohort of 50 patients with malignant renal tumours. Biomarker analyses in blood and urine samples used validated targeted methods for measuring OTA and CIT plus dihydrocitrinone (DH-CIT) after enrichment of analytes by specific immunoaffinity clean-up. OTA and CIT plus its metabolite DH-CITwere frequently detected in patient urine samples (OTA 62%; CIT 91%; DHCIT 100%). The concentration ranges in urine were 1–27.8 ng/L for OTA, 2–87 ng/L for CIT and 2–160 ng/L for DH-CIT. The analyses of blood samples revealed also a frequent co-occurrence of OTA and CIT, in the ranges of 40–870 ng/L serum for OTA and 21–182 ng/L plasma for CIT. This first analysis of biomarkers in blood and urine samples of Czech patients revealed no major differences in comparison with published data for the general healthy Czech and European populations. Nonetheless, a frequent co-occurrence of CIT and OTA biomarkers in patient samples may be of interest with regard to potential interactions with other risk factors for renal disease.

Název v anglickém jazyce

Analyses of biomarkers of exposure to nephrotoxic mycotoxins in a cohort of patients with renal tumours

Popis výsledku anglicky

The Czech Republic occupies the first place in the world in the frequency of renal and other urinary tract tumours, but their aetiology is unknown. To explore whether carcinogenic and nephrotoxic mycotoxins may contribute to kidney diseases in the Czech population, biomarkers of ochratoxin A (OTA) and citrinin (CIT) exposure were determined in biological specimens from a cohort of 50 patients with malignant renal tumours. Biomarker analyses in blood and urine samples used validated targeted methods for measuring OTA and CIT plus dihydrocitrinone (DH-CIT) after enrichment of analytes by specific immunoaffinity clean-up. OTA and CIT plus its metabolite DH-CITwere frequently detected in patient urine samples (OTA 62%; CIT 91%; DHCIT 100%). The concentration ranges in urine were 1–27.8 ng/L for OTA, 2–87 ng/L for CIT and 2–160 ng/L for DH-CIT. The analyses of blood samples revealed also a frequent co-occurrence of OTA and CIT, in the ranges of 40–870 ng/L serum for OTA and 21–182 ng/L plasma for CIT. This first analysis of biomarkers in blood and urine samples of Czech patients revealed no major differences in comparison with published data for the general healthy Czech and European populations. Nonetheless, a frequent co-occurrence of CIT and OTA biomarkers in patient samples may be of interest with regard to potential interactions with other risk factors for renal disease.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10620 - Other biological topics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mycotoxin research

ISSN

0178-7888

e-ISSN

—

Svazek periodika

35

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

391-403

Kód UT WoS článku

000491496300008

EID výsledku v databázi Scopus

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