Tetraspanins in mammalian reproduction: spermatozoa, oocytes and embryos

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50020155" target="_blank" >RIV/62690094:18470/20:50020155 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652036:_____/20:00534677 RIV/60460709:41210/20:81701 RIV/00216208:11310/20:10418183

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00430-020-00676-0" target="_blank" >https://link.springer.com/article/10.1007/s00430-020-00676-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00430-020-00676-0" target="_blank" >10.1007/s00430-020-00676-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tetraspanins in mammalian reproduction: spermatozoa, oocytes and embryos

Popis výsledku v původním jazyce

It is known that tetraspanin proteins are involved in many physiological somatic cell mechanisms. Additionally, research has indicated they also have a role in various infectious diseases and cancers. This review focuses on the molecular interactions underlying the tetraspanin web formation in gametes. Primarily, tetraspanins act in the reproductive tract as organizers of membrane complexes, which include the proteins involved in the contact and association of sperm and oocyte membranes. In addition, recent data shows that tetraspanins are likely to be involved in these processes in a complex way. In mammalian fertilization, an important role is attributed to CD molecules belonging to the tetraspanin superfamily, particularly CD9, CD81, CD151, and also CD63; mostly as part of extracellular vesicles, the significance of which and their potential in reproduction is being intensively investigated. In this article, we reviewed the existing knowledge regarding the expression of tetraspanins CD9, CD81, CD151, and CD63 in mammalian spermatozoa, oocytes, and embryos and their involvement in reproductive processes, including pathological events.

Název v anglickém jazyce

Tetraspanins in mammalian reproduction: spermatozoa, oocytes and embryos

Popis výsledku anglicky

It is known that tetraspanin proteins are involved in many physiological somatic cell mechanisms. Additionally, research has indicated they also have a role in various infectious diseases and cancers. This review focuses on the molecular interactions underlying the tetraspanin web formation in gametes. Primarily, tetraspanins act in the reproductive tract as organizers of membrane complexes, which include the proteins involved in the contact and association of sperm and oocyte membranes. In addition, recent data shows that tetraspanins are likely to be involved in these processes in a complex way. In mammalian fertilization, an important role is attributed to CD molecules belonging to the tetraspanin superfamily, particularly CD9, CD81, CD151, and also CD63; mostly as part of extracellular vesicles, the significance of which and their potential in reproduction is being intensively investigated. In this article, we reviewed the existing knowledge regarding the expression of tetraspanins CD9, CD81, CD151, and CD63 in mammalian spermatozoa, oocytes, and embryos and their involvement in reproductive processes, including pathological events.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MEDICAL MICROBIOLOGY AND IMMUNOLOGY

ISSN

0300-8584

e-ISSN

1432-1831

Svazek periodika

209

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

19

Strana od-do

407-425

Kód UT WoS článku

000533800300001

EID výsledku v databázi Scopus

2-s2.0-85084855927