The role of microRNA-21 in the onset and progression of cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50018386" target="_blank" >RIV/62690094:18470/21:50018386 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/21:10435233 RIV/00179906:_____/21:10435233

Výsledek na webu

<a href="https://www.future-science.com/doi/abs/10.4155/fmc-2021-0096" target="_blank" >https://www.future-science.com/doi/abs/10.4155/fmc-2021-0096</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4155/fmc-2021-0096" target="_blank" >10.4155/fmc-2021-0096</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of microRNA-21 in the onset and progression of cancer

Popis výsledku v původním jazyce

MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the downregulation of tumor suppressor genes, the miR-21 is also associated with cancer resistance to various chemotherapy. The recent research is appraising miR-21 as a promising cancer target and biomarker for early cancer detection. In this review, we briefly explain the biogenesis and regulation of miR-21 in cancer cells. Additionally, the review features the assorted genes/pathways regulated by the miR-21 in various cancer and cancer stem cells.

Název v anglickém jazyce

The role of microRNA-21 in the onset and progression of cancer

Popis výsledku anglicky

MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the downregulation of tumor suppressor genes, the miR-21 is also associated with cancer resistance to various chemotherapy. The recent research is appraising miR-21 as a promising cancer target and biomarker for early cancer detection. In this review, we briefly explain the biogenesis and regulation of miR-21 in cancer cells. Additionally, the review features the assorted genes/pathways regulated by the miR-21 in various cancer and cancer stem cells.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Future medicinal chemistry

ISSN

1756-8919

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

22

Strana od-do

1885-1906

Kód UT WoS článku

000701850400001

EID výsledku v databázi Scopus

2-s2.0-85117823305