Essential metals in health and disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50019426" target="_blank" >RIV/62690094:18470/22:50019426 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/22:10449528

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0009279722003787" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0009279722003787</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cbi.2022.110173" target="_blank" >10.1016/j.cbi.2022.110173</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Essential metals in health and disease

Popis výsledku v původním jazyce

In total, twenty elements appear to be essential for the correct functioning of the human body,half of which are metals and half are non-metals. Among those metals that are currentlyconsidered to be essential for normal biological functioning are four main group elements,sodium (Na), potassium (K), magnesium (Mg), and calcium (Ca), and six d-block transition metalelements, manganese (Mn), iron (Fe), cobalt (Co), copper (Cu), zinc (Zn) and molybdenum (Mo).Cells have developed various metallo-regulatory mechanisms for maintaining a necessaryhomeostasis of metal-ions for diverse cellular processes, most importantly in the central nervoussystem. Since redox active transition metals (for example Fe and Cu) may participate in electrontransfer reactions, their homeostasis must be carefully controlled. The catalytic behaviour ofredox metals which have escaped control, e.g. via the Fenton reaction, results in the formationof reactive hydroxyl radicals, which may cause damage to DNA, proteins and membranes.Transition metals are integral parts of the active centres of numerous enzymes (e.Dg. Cu,Zn-SOD,Mn-SOD, Catalase) which catalyze chemical reactions at physiologically compatible rates. Eithera deficiency, or an excess of essential metals may result in various disease states arising in anorganism. Some typical ailments that are characterized by a disturbed homeostasis of redoxactive metals include neurological disorders (Alzheimer’s, Parkinson’s and Huntington’sdisorders), mental health problems, cardiovascular diseases, cancer, and diabetes. Tocomprehend more deeply the mechanisms by which essential metals, acting either alone or incombination, and/or through their interaction with non-essential metals (e.g. chromium)function in biological systems will require the application of a broader, more interdisciplinaryapproach than has mainly been used so far. It is clear that a stronger cooperation betweenbioinorganic chemists and biophysicists - who have already achieved great success inunderstanding the structure and role of metalloenzymes in living systems - with biologists, willaccess new avenues of research in the systems biology of metal ions. With this in mind, thepresent paper reviews selected chemical and biological aspects of metal ions and their possibleinteractions in living systems under normal and pathological conditions.

Název v anglickém jazyce

Essential metals in health and disease

Popis výsledku anglicky

In total, twenty elements appear to be essential for the correct functioning of the human body,half of which are metals and half are non-metals. Among those metals that are currentlyconsidered to be essential for normal biological functioning are four main group elements,sodium (Na), potassium (K), magnesium (Mg), and calcium (Ca), and six d-block transition metalelements, manganese (Mn), iron (Fe), cobalt (Co), copper (Cu), zinc (Zn) and molybdenum (Mo).Cells have developed various metallo-regulatory mechanisms for maintaining a necessaryhomeostasis of metal-ions for diverse cellular processes, most importantly in the central nervoussystem. Since redox active transition metals (for example Fe and Cu) may participate in electrontransfer reactions, their homeostasis must be carefully controlled. The catalytic behaviour ofredox metals which have escaped control, e.g. via the Fenton reaction, results in the formationof reactive hydroxyl radicals, which may cause damage to DNA, proteins and membranes.Transition metals are integral parts of the active centres of numerous enzymes (e.Dg. Cu,Zn-SOD,Mn-SOD, Catalase) which catalyze chemical reactions at physiologically compatible rates. Eithera deficiency, or an excess of essential metals may result in various disease states arising in anorganism. Some typical ailments that are characterized by a disturbed homeostasis of redoxactive metals include neurological disorders (Alzheimer’s, Parkinson’s and Huntington’sdisorders), mental health problems, cardiovascular diseases, cancer, and diabetes. Tocomprehend more deeply the mechanisms by which essential metals, acting either alone or incombination, and/or through their interaction with non-essential metals (e.g. chromium)function in biological systems will require the application of a broader, more interdisciplinaryapproach than has mainly been used so far. It is clear that a stronger cooperation betweenbioinorganic chemists and biophysicists - who have already achieved great success inunderstanding the structure and role of metalloenzymes in living systems - with biologists, willaccess new avenues of research in the systems biology of metal ions. With this in mind, thepresent paper reviews selected chemical and biological aspects of metal ions and their possibleinteractions in living systems under normal and pathological conditions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemico-biological interactions

ISSN

0009-2797

e-ISSN

1872-7786

Svazek periodika

367

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

28

Strana od-do

"Article number: 110173"

Kód UT WoS článku

000868270300005

EID výsledku v databázi Scopus

2-s2.0-85138599128