Dysbiosis significantly elevates the probability of altered affective function in Alzheimer disease (AD)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F25%3A50022370" target="_blank" >RIV/62690094:18470/25:50022370 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/bs.irn.2025.04.005" target="_blank" >http://dx.doi.org/10.1016/bs.irn.2025.04.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/bs.irn.2025.04.005" target="_blank" >10.1016/bs.irn.2025.04.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dysbiosis significantly elevates the probability of altered affective function in Alzheimer disease (AD)

Popis výsledku v původním jazyce

Changes in the makeup of gut microbiota are linked to many neuropsychiatric diseases. Although the exact connection between gut dysbiosis and brain dysfunction is not yet fully understood, but recent data suggests that gut dysbiosis may contribute to the development of Alzheimer’s disease (AD) by promoting neuroinflammation, insulin resistance, oxidative stress, and amyloid-beta (Aβ) aggregation. Gut dysbiosis in animal models is primarily characterized by an elevated ratio of Firmicutes/Bacteroidetes which may lead to the accumulation of amyloid precursor protein (APP) in the intestine, in the early stages of AD. Probiotics play a significant role in preventing against the symptoms of AD by restoring gut-brain homeostasis. This chapter provides an overview of the gut microbiota and its dysregulation in etiology of AD. Moreover, novel insights into alteration of the composition of gut microbiota as a preventive or therapeutic approach to AD are discussed.

Název v anglickém jazyce

Dysbiosis significantly elevates the probability of altered affective function in Alzheimer disease (AD)

Popis výsledku anglicky

Changes in the makeup of gut microbiota are linked to many neuropsychiatric diseases. Although the exact connection between gut dysbiosis and brain dysfunction is not yet fully understood, but recent data suggests that gut dysbiosis may contribute to the development of Alzheimer’s disease (AD) by promoting neuroinflammation, insulin resistance, oxidative stress, and amyloid-beta (Aβ) aggregation. Gut dysbiosis in animal models is primarily characterized by an elevated ratio of Firmicutes/Bacteroidetes which may lead to the accumulation of amyloid precursor protein (APP) in the intestine, in the early stages of AD. Probiotics play a significant role in preventing against the symptoms of AD by restoring gut-brain homeostasis. This chapter provides an overview of the gut microbiota and its dysregulation in etiology of AD. Moreover, novel insights into alteration of the composition of gut microbiota as a preventive or therapeutic approach to AD are discussed.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

International Review of Neurobiology

ISBN

978-0-443-31648-7

Počet stran výsledku

24

Strana od-do

1-24

Počet stran knihy

526

Název nakladatele

Elsevier Inc.

Místo vydání

San Diego

Kód UT WoS kapitoly

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