Dissolution of fluconazole from 3D-printed prolonged-release tablets: a quantitative evaluation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F25%3A50023035" target="_blank" >RIV/62690094:18470/25:50023035 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0378517325010282?pes=vor&utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517325010282?pes=vor&utm_source=clarivate&getft_integrator=clarivate</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2025.126191" target="_blank" >10.1016/j.ijpharm.2025.126191</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dissolution of fluconazole from 3D-printed prolonged-release tablets: a quantitative evaluation

Popis výsledku v původním jazyce

Among the many applications of additive technologies, their use in drug formulation holds a particularly important place. Numerous studies have been conducted on using various 3D printing techniques to produce both immediate- and modified-release dosage forms. However, the drug release mechanism may vary depending on the manufacturing method and formulation composition. This work aimed to analyze the influence of the 3D printing method used on the mechanism of fluconazole release from prolonged-release tablets. We conducted an analysis of tablets containing 50 mg of fluconazole, produced using two 3D printing techniques: Fused Deposition Modeling (FDM) and Liquid Crystal Display (LCD, classified as one of the Vat Photopolymerization (VPP) methods). Because FDM and VPP techniques build objects in fundamentally different ways, a unique set of excipients was used for each of these methods. For the FDMprinted tablets, poly(vinyl alcohol) was used to control drug release and as the filament-forming polymer. The tablet matrix produced using the VPP method was based on the cross-linked polyethylene glycol diacrylate. Both formulations were characterized by prolonged release of API. Employing surface dissolution imaging and kinetic models, we demonstrated that in the case of FDM-printed tablets, the API release is mainly regulated by the relaxation and gradual decay of the water-soluble polymer. In contrast, the relaxation of the water-insoluble matrix of VPP tablets was negligible. Although the diameter of the VPP tablets increased slightly during the dissolution study, the API release was primarily controlled by the diffusion of fluconazole through the crosslinked polymer.

Název v anglickém jazyce

Dissolution of fluconazole from 3D-printed prolonged-release tablets: a quantitative evaluation

Popis výsledku anglicky

Among the many applications of additive technologies, their use in drug formulation holds a particularly important place. Numerous studies have been conducted on using various 3D printing techniques to produce both immediate- and modified-release dosage forms. However, the drug release mechanism may vary depending on the manufacturing method and formulation composition. This work aimed to analyze the influence of the 3D printing method used on the mechanism of fluconazole release from prolonged-release tablets. We conducted an analysis of tablets containing 50 mg of fluconazole, produced using two 3D printing techniques: Fused Deposition Modeling (FDM) and Liquid Crystal Display (LCD, classified as one of the Vat Photopolymerization (VPP) methods). Because FDM and VPP techniques build objects in fundamentally different ways, a unique set of excipients was used for each of these methods. For the FDMprinted tablets, poly(vinyl alcohol) was used to control drug release and as the filament-forming polymer. The tablet matrix produced using the VPP method was based on the cross-linked polyethylene glycol diacrylate. Both formulations were characterized by prolonged release of API. Employing surface dissolution imaging and kinetic models, we demonstrated that in the case of FDM-printed tablets, the API release is mainly regulated by the relaxation and gradual decay of the water-soluble polymer. In contrast, the relaxation of the water-insoluble matrix of VPP tablets was negligible. Although the diameter of the VPP tablets increased slightly during the dissolution study, the API release was primarily controlled by the diffusion of fluconazole through the crosslinked polymer.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Pharmaceutics

ISSN

0378-5173

e-ISSN

1873-3476

Svazek periodika

685

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

"Article Number: 126191"

Kód UT WoS článku

001583688200005

EID výsledku v databázi Scopus

2-s2.0-105020835431