Genotoxic and non-genotoxic effects of organic air pollution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F64608531%3A_____%2F03%3AT07" target="_blank" >RIV/64608531:_____/03:T07 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Genotoxic and non-genotoxic effects of organic air pollution

Popis výsledku v původním jazyce

Air pollution has generally been recognized as a health hazard. Adverse health effects are mainly related to persistent organic pollutants. In air, they are either bound to the particulate matter or in a volatile form. Besides PAHs, there are also theirderivatives. A large amount of these derivatives comes from transformation reactions of PAHs in air. This study was focused on identification of health risks of the organic air pollution mixtures with the emphasis on genotoxicity (SOS chromotest, -S9/+S9and a dioxin toxicity (cell-line H4IIE.luc). The organic extracts of TSP and fine particles were studied. Genotoxicity was caused mainly by direct genotoxins that are bound in larger particles. Progenotoxic compounds were mainly in the fine particles. The dioxin toxicity is related mainly to PAHs. The results showed that the derivatives of PAHs were responsible for a significant part of the toxic potency of the organic air pollution. A part of them is bound in the non-respirable particle

Název v anglickém jazyce

Genotoxic and non-genotoxic effects of organic air pollution

Popis výsledku anglicky

Air pollution has generally been recognized as a health hazard. Adverse health effects are mainly related to persistent organic pollutants. In air, they are either bound to the particulate matter or in a volatile form. Besides PAHs, there are also theirderivatives. A large amount of these derivatives comes from transformation reactions of PAHs in air. This study was focused on identification of health risks of the organic air pollution mixtures with the emphasis on genotoxicity (SOS chromotest, -S9/+S9and a dioxin toxicity (cell-line H4IIE.luc). The organic extracts of TSP and fine particles were studied. Genotoxicity was caused mainly by direct genotoxins that are bound in larger particles. Progenotoxic compounds were mainly in the fine particles. The dioxin toxicity is related mainly to PAHs. The results showed that the derivatives of PAHs were responsible for a significant part of the toxic potency of the organic air pollution. A part of them is bound in the non-respirable particle

Druh

D - Stať ve sborníku

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

<a href="/cs/project/SJ%2F740%2F2%2F01" target="_blank" >SJ/740/2/01: Transformace látek znečišťujících ovzduší ve vztahu k negativním antropogenním procesům, k jejich účinkům na lidskou populaci, krajinné receptory a k modelování jejich přenosu v atmosféře.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Setac Europe, 14th Annual Meeting Prague, Czech Republic 18.4. - 22.4.2004

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

184-184

Název nakladatele

MZP

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

18. 4. 2004

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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