The association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute heart Failure and Left ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary percutaneous Coronary Intervention
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001645" target="_blank" >RIV/65269705:_____/12:#0001645 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14110/12:00064899 RIV/00159816:_____/12:00060682
Výsledek na webu
<a href="http://dx.doi.org/10.1089/gtmb.2012.0120" target="_blank" >http://dx.doi.org/10.1089/gtmb.2012.0120</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/gtmb.2012.0120" target="_blank" >10.1089/gtmb.2012.0120</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute heart Failure and Left ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary percutaneous Coronary Intervention
Popis výsledku v původním jazyce
Aims: Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. Methods: In total, 556 patients with STEMI were evaluated. Levels ofTIMP-1 were measured at admission and 24?h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. Results: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was
Název v anglickém jazyce
The association Between Levels of Tissue Inhibitor of Metalloproteinase-1 with Acute heart Failure and Left ventricular Dysfunction in Patients with ST Elevation Myocardial Infarction Treated by Primary percutaneous Coronary Intervention
Popis výsledku anglicky
Aims: Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. Methods: In total, 556 patients with STEMI were evaluated. Levels ofTIMP-1 were measured at admission and 24?h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. Results: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Genetic Testing and Molecular Biomarkers
ISSN
1945-0265
e-ISSN
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Svazek periodika
16
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
1172-1178
Kód UT WoS článku
000309957500004
EID výsledku v databázi Scopus
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