ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00040848" target="_blank" >RIV/00216224:14110/10:00040848 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

Popis výsledku v původním jazyce

We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction left ventricular dysfunction and acute heart failure early after presentation with MI with ST-segment elevation. A total of 556 patients with STEMI treated by primary PCI were the study population. The DD/ID genotypes were associated with a significantly higher risk of EF. These results suggest that the I/D polymorphism of ACE is associated withthe development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity thanpatients with preserved LV function.

Název v anglickém jazyce

ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

Popis výsledku anglicky

We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction left ventricular dysfunction and acute heart failure early after presentation with MI with ST-segment elevation. A total of 556 patients with STEMI treated by primary PCI were the study population. The DD/ID genotypes were associated with a significantly higher risk of EF. These results suggest that the I/D polymorphism of ACE is associated withthe development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity thanpatients with preserved LV function.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS9880" target="_blank" >NS9880: Komplexní managment péče o pacienty as akutním srdečním selháním, jejichstřednědobá prognóza a multivariantní prognostický model</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Cardiovascular Disorders

ISSN

1471-2261

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

60

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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