MRAS gene marker rs9818870 is not associated with acute coronary syndrome in the Czech population and does not predict mortality in males after acute coronary syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00076221" target="_blank" >RIV/00023001:_____/17:00076221 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/17:10366594

Výsledek na webu

<a href="http://www.advances.am.wroc.pl/pdf/2017/26/8/1213.pdf" target="_blank" >http://www.advances.am.wroc.pl/pdf/2017/26/8/1213.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17219/acem/67460" target="_blank" >10.17219/acem/67460</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MRAS gene marker rs9818870 is not associated with acute coronary syndrome in the Czech population and does not predict mortality in males after acute coronary syndrome

Popis výsledku v původním jazyce

Background. Genome-wide association studies (GWAs) focused on cardiovascular diseases reveal variants within genes which have not been analyzed through the pre-GWAs era, and whose function is often unknown. One of them is variant rs9818870 at the MRAS gene locus. Objectives. To analyze if MRAS polymorphism is associated with acute coronary syndrome (ACS) risk in a Czech population and with mortality in male patients after myocardial infarction. Material and methods. 1,779 male patients with ACS (aged 55.3 +/- 7.9 years) and 673 female patients with ACS (aged 64.0 +/- 8.1 years) were genotyped for rs9818870 polymorphism using the PCR-RFLP method. In a subset of 1,221 patients, detailed diagnoses (901 subjects with STEMI, 280 subjects with NSTEMI, 40 cases with unstable angina pectoris) were recorded. In 1,614 males, records about total and cardiovascular mortality were available. Results. Whether the entire populations or males and females have been analyzed separately or not, we have not confirmed the described association between DNA marker rs9818870 and ACS in Czechs (30.4% vs 29.4% carriers of the minor T allele [ recessive model], p = 0.54; OR 1.05; 95% CI 0.89-1.24 for males and 32.1% vs 29.7% carriers of the minor T allele, p = 0.28; OR 1.12; 95% CI 0.91-1.37 for females). Types of the ACS (STEMI and NSTEMI) or mortality (in males only) were not associated with the analyzed polymorphism (all p &gt; 0.34). Conclusions. The rs9818870 variant is not associated with ACS or mortality in ACS patients in the Czech Slavonic population.

Název v anglickém jazyce

MRAS gene marker rs9818870 is not associated with acute coronary syndrome in the Czech population and does not predict mortality in males after acute coronary syndrome

Popis výsledku anglicky

Background. Genome-wide association studies (GWAs) focused on cardiovascular diseases reveal variants within genes which have not been analyzed through the pre-GWAs era, and whose function is often unknown. One of them is variant rs9818870 at the MRAS gene locus. Objectives. To analyze if MRAS polymorphism is associated with acute coronary syndrome (ACS) risk in a Czech population and with mortality in male patients after myocardial infarction. Material and methods. 1,779 male patients with ACS (aged 55.3 +/- 7.9 years) and 673 female patients with ACS (aged 64.0 +/- 8.1 years) were genotyped for rs9818870 polymorphism using the PCR-RFLP method. In a subset of 1,221 patients, detailed diagnoses (901 subjects with STEMI, 280 subjects with NSTEMI, 40 cases with unstable angina pectoris) were recorded. In 1,614 males, records about total and cardiovascular mortality were available. Results. Whether the entire populations or males and females have been analyzed separately or not, we have not confirmed the described association between DNA marker rs9818870 and ACS in Czechs (30.4% vs 29.4% carriers of the minor T allele [ recessive model], p = 0.54; OR 1.05; 95% CI 0.89-1.24 for males and 32.1% vs 29.7% carriers of the minor T allele, p = 0.28; OR 1.12; 95% CI 0.91-1.37 for females). Types of the ACS (STEMI and NSTEMI) or mortality (in males only) were not associated with the analyzed polymorphism (all p &gt; 0.34). Conclusions. The rs9818870 variant is not associated with ACS or mortality in ACS patients in the Czech Slavonic population.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NT12217" target="_blank" >NT12217: Genetické faktory určující riziko aterotrombotických cévních příhod u nemocných bez klasických rizikových faktorů aterosklerózy a u pacientů léčených statinem</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advances in clinical and experimental medicine

ISSN

1899-5276

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

5

Strana od-do

1213-1217

Kód UT WoS článku

000418449900006

EID výsledku v databázi Scopus

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