Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909624" target="_blank" >RIV/00216208:11120/15:43909624 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/15:10295982 RIV/00064203:_____/15:10295982 RIV/00023001:_____/15:00059495 RIV/00064165:_____/15:10295982 RIV/00023884:_____/15:#0007163

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11033-015-3870-1" target="_blank" >http://dx.doi.org/10.1007/s11033-015-3870-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11033-015-3870-1" target="_blank" >10.1007/s11033-015-3870-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome

Popis výsledku v původním jazyce

Myocardial infarction (MI) is the leading cause of death in industrialized countries. All the traditional risk factors for MI are responsible for approximately 50 % of cases of MI cases. Attention therefore has recently focused on genetic variants that are not associated with conventional risk factors. One of them is the marker rs6922269, which has been suggested as a risk factor for development of MI in Western populations. We analyzed the relationship between rs6922269 variant on MTHFD1L gene and (i) risk of the acute coronary syndrome (ACS) in the Czech population and (ii) mortality in 7 years follow up. Rs6922269 (G>A) variant was analyzed (CR 99.3 % for patients and 98.0 % for controls) by PCR-RFLP in consecutively examined 1614 men and 503 women with ACS (age below 65 years) and in population-based controls--1191 men and 1368 women (aged up to 65 years). ANOVA and Chi square were used for statistical analysis. The genotype frequencies were almost identical (P = 0.87) in the ACS patients and in controls and no differences were observed, if males (P = 0.73) and females (P = 0.93) were analysed separately. In addition, rs6922269 polymorphism was not associated with the classical risk factors (dyslipidemia, hypertension, obesity, smoking, diabetes) in control population. Cardiovascular mortality was significantly higher in males, carriers of the AA genotype (P < 0.001, OR 2.52, 95 % CI 1.40-4.55, for AA vs. +G). We conclude, that rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS.

Název v anglickém jazyce

Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome

Popis výsledku anglicky

Myocardial infarction (MI) is the leading cause of death in industrialized countries. All the traditional risk factors for MI are responsible for approximately 50 % of cases of MI cases. Attention therefore has recently focused on genetic variants that are not associated with conventional risk factors. One of them is the marker rs6922269, which has been suggested as a risk factor for development of MI in Western populations. We analyzed the relationship between rs6922269 variant on MTHFD1L gene and (i) risk of the acute coronary syndrome (ACS) in the Czech population and (ii) mortality in 7 years follow up. Rs6922269 (G>A) variant was analyzed (CR 99.3 % for patients and 98.0 % for controls) by PCR-RFLP in consecutively examined 1614 men and 503 women with ACS (age below 65 years) and in population-based controls--1191 men and 1368 women (aged up to 65 years). ANOVA and Chi square were used for statistical analysis. The genotype frequencies were almost identical (P = 0.87) in the ACS patients and in controls and no differences were observed, if males (P = 0.73) and females (P = 0.93) were analysed separately. In addition, rs6922269 polymorphism was not associated with the classical risk factors (dyslipidemia, hypertension, obesity, smoking, diabetes) in control population. Cardiovascular mortality was significantly higher in males, carriers of the AA genotype (P < 0.001, OR 2.52, 95 % CI 1.40-4.55, for AA vs. +G). We conclude, that rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT12217" target="_blank" >NT12217: Genetické faktory určující riziko aterotrombotických cévních příhod u nemocných bez klasických rizikových faktorů aterosklerózy a u pacientů léčených statinem</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Biology Reports

ISSN

0301-4851

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

1289-1293

Kód UT WoS článku

000358165300006

EID výsledku v databázi Scopus

2-s2.0-84937979177