Manganese in Whole Blood and Hair in Patients with Long-Term Home Parenteral Nutrition

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065000" target="_blank" >RIV/65269705:_____/16:00065000 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00090072

Výsledek na webu

<a href="http://dx.doi.org/10.7754/Clin.Lab.2015.150622" target="_blank" >http://dx.doi.org/10.7754/Clin.Lab.2015.150622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7754/Clin.Lab.2015.150622" target="_blank" >10.7754/Clin.Lab.2015.150622</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Manganese in Whole Blood and Hair in Patients with Long-Term Home Parenteral Nutrition

Popis výsledku v původním jazyce

Background: Manganese is an essential trace element and indispensable component of nutrition mixtures in long-term home parenteral nutrition (HPN) of patients. On the other hand, neurotoxic effects of excess manganese in the organism have been known for a long time. The objective of the present study was to determine manganese concentration in whole blood and hair of patients with long-term home parenteral nutrition. Methods: We examined 16 patients (7 men and 9 women) aged from 28 to 68 years on long-term HPN lasting from 4 to 96 months. The short bowel syndrome was an indication for HPN. The daily dose of manganese ranged between 80 and 470 mu g/day (1.2 to 8.5 mu g/kg/day). Results: In the investigated patients we detected approximately a doubled value of manganese concentration in whole blood in comparison to the control group (16.2 mu g/L; 12.9 - 20.4 mu g/L and 7.4 mu g/L; 6.4 - 8.4 mu g/L). In five patients with symptoms of cholestatic hepatopathy, Mn concentration in whole blood exceeded the value of 20.0 mu g/L. Magnetic resonance of the brain in four of these patients detected a hyperintense T1-signal in the globus pallidus without any clinical symptoms similar to the Parkinson's syndrome. The content of manganese in the patients' hair was also significantly increased (p < 0.04). Conclusions: The results of our study corroborate the necessity of careful monitoring of the manganese concentration in the organism during HPN, especially in patients with liver disorders. Individualized HPN with greater accessibility of variable mixtures of trace elements would certainly be greatly beneficial, at least with regard to problems associated with manganese substitution.

Název v anglickém jazyce

Manganese in Whole Blood and Hair in Patients with Long-Term Home Parenteral Nutrition

Popis výsledku anglicky

Background: Manganese is an essential trace element and indispensable component of nutrition mixtures in long-term home parenteral nutrition (HPN) of patients. On the other hand, neurotoxic effects of excess manganese in the organism have been known for a long time. The objective of the present study was to determine manganese concentration in whole blood and hair of patients with long-term home parenteral nutrition. Methods: We examined 16 patients (7 men and 9 women) aged from 28 to 68 years on long-term HPN lasting from 4 to 96 months. The short bowel syndrome was an indication for HPN. The daily dose of manganese ranged between 80 and 470 mu g/day (1.2 to 8.5 mu g/kg/day). Results: In the investigated patients we detected approximately a doubled value of manganese concentration in whole blood in comparison to the control group (16.2 mu g/L; 12.9 - 20.4 mu g/L and 7.4 mu g/L; 6.4 - 8.4 mu g/L). In five patients with symptoms of cholestatic hepatopathy, Mn concentration in whole blood exceeded the value of 20.0 mu g/L. Magnetic resonance of the brain in four of these patients detected a hyperintense T1-signal in the globus pallidus without any clinical symptoms similar to the Parkinson's syndrome. The content of manganese in the patients' hair was also significantly increased (p < 0.04). Conclusions: The results of our study corroborate the necessity of careful monitoring of the manganese concentration in the organism during HPN, especially in patients with liver disorders. Individualized HPN with greater accessibility of variable mixtures of trace elements would certainly be greatly beneficial, at least with regard to problems associated with manganese substitution.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Laboratory

ISSN

1433-6510

e-ISSN

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Svazek periodika

62

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

173-177

Kód UT WoS článku

000370463700021

EID výsledku v databázi Scopus

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