Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00076248" target="_blank" >RIV/65269705:_____/23:00076248 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00130207 RIV/00209805:_____/23:00079058

Výsledek na webu

<a href="https://www.cambridge.org/core/services/aop-cambridge-core/content/view/F9AE53803D7AA9C4D5C24F1314EE51BF/S0007114522002008a.pdf/long-term-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine.pdf" target="_blank" >https://www.cambridge.org/core/services/aop-cambridge-core/content/view/F9AE53803D7AA9C4D5C24F1314EE51BF/S0007114522002008a.pdf/long-term-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S0007114522002008" target="_blank" >10.1017/S0007114522002008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine

Popis výsledku v původním jazyce

Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 has well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6-75 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn&apos;s disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1.5, 3.4 and 0.68 g/kg per d, respectively, at an infusion rate of 0.11, 0.28 and 0.06 g/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (P &lt; 0.05). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0.11 g/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (P &lt; 0.0001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0.34 % (0-23-0.46) of the administered dose.

Název v anglickém jazyce

Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine

Popis výsledku anglicky

Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 has well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6-75 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn&apos;s disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1.5, 3.4 and 0.68 g/kg per d, respectively, at an infusion rate of 0.11, 0.28 and 0.06 g/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (P &lt; 0.05). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0.11 g/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (P &lt; 0.0001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0.34 % (0-23-0.46) of the administered dose.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British Journal of Nutrition

ISSN

0007-1145

e-ISSN

1475-2662

Svazek periodika

129

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

1537-1542

Kód UT WoS článku

000850370000001

EID výsledku v databázi Scopus

2-s2.0-85153583578