Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00068522" target="_blank" >RIV/65269705:_____/18:00068522 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14110/18:00102134
Výsledek na webu
<a href="http://dx.doi.org/10.1080/14767058.2017.1323530" target="_blank" >http://dx.doi.org/10.1080/14767058.2017.1323530</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14767058.2017.1323530" target="_blank" >10.1080/14767058.2017.1323530</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
Popis výsledku v původním jazyce
Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
Název v anglickém jazyce
Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
Popis výsledku anglicky
Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30214 - Obstetrics and gynaecology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
ISSN
1476-7058
e-ISSN
—
Svazek periodika
31
Číslo periodika v rámci svazku
13
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
7
Strana od-do
1689-1695
Kód UT WoS článku
000430732400003
EID výsledku v databázi Scopus
2-s2.0-85019214172