T Cell Receptor Repertoire in Systemic Anaplastic Large Cell Lymphoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00071936" target="_blank" >RIV/65269705:_____/19:00071936 - isvavai.cz</a>

Výsledek na webu

<a href="http://phdretreat.ceitec.cz/joint-retreat-2019/" target="_blank" >http://phdretreat.ceitec.cz/joint-retreat-2019/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

T Cell Receptor Repertoire in Systemic Anaplastic Large Cell Lymphoma

Popis výsledku v původním jazyce

Systemic Anaplastic Large Cell Lymphoma (sALCL) is a genetically heterogenous disease and it encompasses two different clinical entities of T-cell lymphomas: ALKpositive ALCL characterized by ALK-translocation, and ALK-negative ALCL, delineated by lack of the latter. Although sALCL is a T cell lymphoma it is characterized by lack of T cell receptor (TcR) expression on the cell surface. Since T cells are largely dependent on signals that they receive from their TcR for their development and maturation, this signaling pathway appears to play a key role in lymphomagenesis. Previous works showed that a considerable percentage of ALK-positive ALCL have fully a rearranged TcR loci and that TcR expression is suppressed during the transformation. Contradictory to this, in ALK-negative ALCL the role of TcR is not fully investigated and its involvement in the lymphoma pathogenesis is completely unknown. To better understand the potential contribution of the TcR in sALCL lymphomagenesis, we perform TcR gene repertoire profiling utilizing targeted, amplicon based, high-throughput re-sequencing methodologies. The deep antigen receptor immunogenetic analysis will allow us to investigate the immunogenetic features distinctive among the two sALCL entities that could delineate differences in their pathogenic mechanisms or within the same entity, where their matching with a distinct clinical behavior may render clinical and therapeutic relevance in this analysis.

Název v anglickém jazyce

T Cell Receptor Repertoire in Systemic Anaplastic Large Cell Lymphoma

Popis výsledku anglicky

Systemic Anaplastic Large Cell Lymphoma (sALCL) is a genetically heterogenous disease and it encompasses two different clinical entities of T-cell lymphomas: ALKpositive ALCL characterized by ALK-translocation, and ALK-negative ALCL, delineated by lack of the latter. Although sALCL is a T cell lymphoma it is characterized by lack of T cell receptor (TcR) expression on the cell surface. Since T cells are largely dependent on signals that they receive from their TcR for their development and maturation, this signaling pathway appears to play a key role in lymphomagenesis. Previous works showed that a considerable percentage of ALK-positive ALCL have fully a rearranged TcR loci and that TcR expression is suppressed during the transformation. Contradictory to this, in ALK-negative ALCL the role of TcR is not fully investigated and its involvement in the lymphoma pathogenesis is completely unknown. To better understand the potential contribution of the TcR in sALCL lymphomagenesis, we perform TcR gene repertoire profiling utilizing targeted, amplicon based, high-throughput re-sequencing methodologies. The deep antigen receptor immunogenetic analysis will allow us to investigate the immunogenetic features distinctive among the two sALCL entities that could delineate differences in their pathogenic mechanisms or within the same entity, where their matching with a distinct clinical behavior may render clinical and therapeutic relevance in this analysis.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/LM2015091" target="_blank" >LM2015091: Národní centrum lékařské genomiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů