Dysconnectivity of the cerebellum and somatomotor network correlates with the severity of alogia in chronic schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00080352" target="_blank" >RIV/65269705:_____/24:00080352 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00137175

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0925492724001069?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0925492724001069?pes=vor</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pscychresns.2024.111883" target="_blank" >10.1016/j.pscychresns.2024.111883</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dysconnectivity of the cerebellum and somatomotor network correlates with the severity of alogia in chronic schizophrenia

Popis výsledku v původním jazyce

Recent fMRI resting-state findings show aberrant functional connectivity within somatomotor network (SMN) in schizophrenia. Moreover, functional connectivity aberrations of the motor system are often reported to be related to the severity of psychotic symptoms. Thus, it is important to validate those findings and confirm their relationship with psychopathology. Therefore, we decided to take an entirely data-driven approach in our fMRI resting-state study of 30 chronic schizophrenia outpatients and 30 matched control subjects. We used independent component analysis (ICA), dual regression, and seed-based connectivity analysis. We found reduced functional connectivity within SMN in schizophrenia patients compared to controls and SMN hypoconnectivity with the cerebellum in schizophrenia patients. The latter was strongly correlated with the severity of alogia, one of the main psychotic symptoms, i.e. poverty of speech and reduction in spontaneous speech,. Our results are consistent with the recent knowledge about the role of the cerebellum in cognitive functioning and its abnormalities in psychiatric disorders, e.g. schizophrenia. In conclusion, the presented results, for the first time clearly showed the involvement of the cerebellum hypoconnectivity with SMN in the persistence and severity of alogia symptoms in schizophrenia. (C) 2024 The Authors

Název v anglickém jazyce

Dysconnectivity of the cerebellum and somatomotor network correlates with the severity of alogia in chronic schizophrenia

Popis výsledku anglicky

Recent fMRI resting-state findings show aberrant functional connectivity within somatomotor network (SMN) in schizophrenia. Moreover, functional connectivity aberrations of the motor system are often reported to be related to the severity of psychotic symptoms. Thus, it is important to validate those findings and confirm their relationship with psychopathology. Therefore, we decided to take an entirely data-driven approach in our fMRI resting-state study of 30 chronic schizophrenia outpatients and 30 matched control subjects. We used independent component analysis (ICA), dual regression, and seed-based connectivity analysis. We found reduced functional connectivity within SMN in schizophrenia patients compared to controls and SMN hypoconnectivity with the cerebellum in schizophrenia patients. The latter was strongly correlated with the severity of alogia, one of the main psychotic symptoms, i.e. poverty of speech and reduction in spontaneous speech,. Our results are consistent with the recent knowledge about the role of the cerebellum in cognitive functioning and its abnormalities in psychiatric disorders, e.g. schizophrenia. In conclusion, the presented results, for the first time clearly showed the involvement of the cerebellum hypoconnectivity with SMN in the persistence and severity of alogia symptoms in schizophrenia. (C) 2024 The Authors

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatry Research-Neuroimaging

ISSN

0925-4927

e-ISSN

1872-7506

Svazek periodika

345

Číslo periodika v rámci svazku

DEC 2024

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

111883

Kód UT WoS článku

001309486700001

EID výsledku v databázi Scopus

2-s2.0-85203011253