The influence of depth of sedation on motor evoked potentials monitoring in youth from 4 to 23 years old: preliminary data from a prospective observational study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00080535" target="_blank" >RIV/65269705:_____/24:00080535 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00137720

Výsledek na webu

<a href="https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1471450/full" target="_blank" >https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1471450/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmed.2024.1471450" target="_blank" >10.3389/fmed.2024.1471450</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The influence of depth of sedation on motor evoked potentials monitoring in youth from 4 to 23 years old: preliminary data from a prospective observational study

Popis výsledku v původním jazyce

Introduction The influence of various levels of sedation depth on motor evoked potentials (MEP) reproducibility in youth is still unclear because of a lack of data. We tested the hypothesis that a deeper level of total intravenous anesthesia (TIVA) [bispectral index (BIS) 40 +/- 5 compared to 60 +/- 5] can affect surgeon-directed MEP and their interpretation in youths.Methods All patients received TIVA combined with propofol and remifentanil. TIVA was initially maintained at a BIS level of 60 +/- 5. The sedation anesthesia was deepened to BIS level 40 +/- 5 before the skin incision. MEP were recorded and interpreted at both BIS levels. The primary endpoint was to evaluate the effect of the depth of sedation on the MEP reproducibility directed and interpreted by the surgical team in each patient separately. The secondary endpoint was to compare the relativized MEP parameters (amplitude and latency) in percentage at various levels of sedation in each patient separately. We planned to enroll 150 patients. Due to the COVID-19 pandemic, we decided to analyze the results of the first 50 patients.Results The surgical team successfully recorded and interpreted MEP in all 50 enrolled patients in both levels of sedation depth without any clinical doubts. The MEP parameters at BIS level 40 +/- 5, proportionally compared with the baseline, were latency 104% (97-110%) and the MEP amplitudes 84.5% (51-109%).Conclusion Preliminary data predict that deeper sedation (BIS 40 +/- 5) does not affect the surgical team&apos;s interpretation of MEP in youth patients. These results support that surgeon-directed MEP may be an alternative when neurophysiologists are unavailable.

Název v anglickém jazyce

The influence of depth of sedation on motor evoked potentials monitoring in youth from 4 to 23 years old: preliminary data from a prospective observational study

Popis výsledku anglicky

Introduction The influence of various levels of sedation depth on motor evoked potentials (MEP) reproducibility in youth is still unclear because of a lack of data. We tested the hypothesis that a deeper level of total intravenous anesthesia (TIVA) [bispectral index (BIS) 40 +/- 5 compared to 60 +/- 5] can affect surgeon-directed MEP and their interpretation in youths.Methods All patients received TIVA combined with propofol and remifentanil. TIVA was initially maintained at a BIS level of 60 +/- 5. The sedation anesthesia was deepened to BIS level 40 +/- 5 before the skin incision. MEP were recorded and interpreted at both BIS levels. The primary endpoint was to evaluate the effect of the depth of sedation on the MEP reproducibility directed and interpreted by the surgical team in each patient separately. The secondary endpoint was to compare the relativized MEP parameters (amplitude and latency) in percentage at various levels of sedation in each patient separately. We planned to enroll 150 patients. Due to the COVID-19 pandemic, we decided to analyze the results of the first 50 patients.Results The surgical team successfully recorded and interpreted MEP in all 50 enrolled patients in both levels of sedation depth without any clinical doubts. The MEP parameters at BIS level 40 +/- 5, proportionally compared with the baseline, were latency 104% (97-110%) and the MEP amplitudes 84.5% (51-109%).Conclusion Preliminary data predict that deeper sedation (BIS 40 +/- 5) does not affect the surgical team&apos;s interpretation of MEP in youth patients. These results support that surgeon-directed MEP may be an alternative when neurophysiologists are unavailable.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Medicine

ISSN

2296-858X

e-ISSN

2296-858X

Svazek periodika

11

Číslo periodika v rámci svazku

OCT 2024

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

1471450

Kód UT WoS článku

001352018100001

EID výsledku v databázi Scopus

2-s2.0-85208610011