Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F17%3A00474103" target="_blank" >RIV/67985807:_____/17:00474103 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10362326 RIV/00064165:_____/17:10362326

Výsledek na webu

<a href="http://dx.doi.org/10.1371/journal.pone.0175509" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0175509</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0175509" target="_blank" >10.1371/journal.pone.0175509</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients

Popis výsledku v původním jazyce

Posterior polymorphous corneal dystrophy (PPCD) is characterized by abnormal proliferation of corneal endothelial cells. It was shown that TGF-beta2 present in aqueous humor (AH) could help maintaining the corneal endothelium in a G1-phase-arrest state. We wanted to determine whether the levels of this protein are changed in AH of PPCD patients. The level of active TGF-beta2 in the AH of all PPCD patients (mean +/- SD, 386.98 +/- 114.88 pg/ml) in comparison to the control group (260.95 +/- 112.43 pg/ml) was significantly higher (P = 0.0001). Compared to the control group, a significantly higher level of active TGF- beta2 was found in the PPCD1 (P = 0.0005) and PPCDx (P = 0.0022) groups. Levels of active TGF- beta2 were not significantly affected by gender, age, secondary glaucoma or by the progression of dystrophy when one or repeated PK were performed.

Název v anglickém jazyce

Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients

Popis výsledku anglicky

Posterior polymorphous corneal dystrophy (PPCD) is characterized by abnormal proliferation of corneal endothelial cells. It was shown that TGF-beta2 present in aqueous humor (AH) could help maintaining the corneal endothelium in a G1-phase-arrest state. We wanted to determine whether the levels of this protein are changed in AH of PPCD patients. The level of active TGF-beta2 in the AH of all PPCD patients (mean +/- SD, 386.98 +/- 114.88 pg/ml) in comparison to the control group (260.95 +/- 112.43 pg/ml) was significantly higher (P = 0.0001). Compared to the control group, a significantly higher level of active TGF- beta2 was found in the PPCD1 (P = 0.0005) and PPCDx (P = 0.0022) groups. Levels of active TGF- beta2 were not significantly affected by gender, age, secondary glaucoma or by the progression of dystrophy when one or repeated PK were performed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10103 - Statistics and probability

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000399874800030

EID výsledku v databázi Scopus

2-s2.0-85017511236