Critical slowing down as a biomarker for seizure susceptibility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F20%3A00524739" target="_blank" >RIV/67985807:_____/20:00524739 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/20:00524739 RIV/00216208:11130/20:10411086 RIV/68407700:21230/20:00341650 RIV/00023752:_____/20:43920250

Výsledek na webu

<a href="https://www.nature.com/articles/s41467-020-15908-3" target="_blank" >https://www.nature.com/articles/s41467-020-15908-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-020-15908-3" target="_blank" >10.1038/s41467-020-15908-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Critical slowing down as a biomarker for seizure susceptibility

Popis výsledku v původním jazyce

The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit critical slowing down, a warning signal preceding many critical transitions in dynamical systems. Using long-term intracranial electroencephalography (iEEG) recordings from fourteen patients with focal epilepsy, we monitored key signatures of critical slowing down prior to seizures. The metrics used to detect critical slowing down fluctuated over temporally long scales (hours to days), longer than would be detectable in standard clinical evaluation settings. Seizure risk was associated with a combination of these signals together with epileptiform discharges. These results provide strong validation of theoretical models and demonstrate that critical slowing down is a reliable indicator that could be used in seizure forecasting algorithms.

Název v anglickém jazyce

Critical slowing down as a biomarker for seizure susceptibility

Popis výsledku anglicky

The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit critical slowing down, a warning signal preceding many critical transitions in dynamical systems. Using long-term intracranial electroencephalography (iEEG) recordings from fourteen patients with focal epilepsy, we monitored key signatures of critical slowing down prior to seizures. The metrics used to detect critical slowing down fluctuated over temporally long scales (hours to days), longer than would be detectable in standard clinical evaluation settings. Seizure risk was associated with a combination of these signals together with epileptiform discharges. These results provide strong validation of theoretical models and demonstrate that critical slowing down is a reliable indicator that could be used in seizure forecasting algorithms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NV17-28427A" target="_blank" >NV17-28427A: Význam funkční a strukturální reorganizace mozkových sítí v patogenezi kognitivního deficitu a epilepsie po cévní mozkové příhodě.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Communications

ISSN

2041-1723

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

2172

Kód UT WoS článku

000531425900014

EID výsledku v databázi Scopus

2-s2.0-85082328143