Milling of pharmaceutical powder carrier excipients: Application of central composite design

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F22%3A00565992" target="_blank" >RIV/67985807:_____/22:00565992 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/22:10451062

Výsledek na webu

<a href="https://dx.doi.org/10.1016/j.apt.2022.103881" target="_blank" >https://dx.doi.org/10.1016/j.apt.2022.103881</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apt.2022.103881" target="_blank" >10.1016/j.apt.2022.103881</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Milling of pharmaceutical powder carrier excipients: Application of central composite design

Popis výsledku v původním jazyce

Pharmaceutical powder carriers are often used to prevent agglomeration of a micronized drug in the co-milling process. Twenty-four pharmaceutical excipients were subjected to preliminary mild milling conditions in this work. Ten of them showed acceptable milling properties with alginic acid, calcium alginate, microcrystalline cellulose (Avicel® 200), carrageenan, and hypromellose having the best particle size reduction without any aggregation while maintaining a narrow span. For the latter five substances, circumscribed central composite design (CCD) evaluating the effect of the factors milling speed and timeon the responses (particle size, particle size distribution) for three milling ball sizes was used to establish optimal milling conditions. For all ten possible factor combinations and each ball size, a quadratic response surface model was used to predict the response variable. For three substances out of five, the best results were achieved using 5-mm balls. Thermal characteristics showed the good stability of excipients under optimized milling conditions.

Název v anglickém jazyce

Milling of pharmaceutical powder carrier excipients: Application of central composite design

Popis výsledku anglicky

Pharmaceutical powder carriers are often used to prevent agglomeration of a micronized drug in the co-milling process. Twenty-four pharmaceutical excipients were subjected to preliminary mild milling conditions in this work. Ten of them showed acceptable milling properties with alginic acid, calcium alginate, microcrystalline cellulose (Avicel® 200), carrageenan, and hypromellose having the best particle size reduction without any aggregation while maintaining a narrow span. For the latter five substances, circumscribed central composite design (CCD) evaluating the effect of the factors milling speed and timeon the responses (particle size, particle size distribution) for three milling ball sizes was used to establish optimal milling conditions. For all ten possible factor combinations and each ball size, a quadratic response surface model was used to predict the response variable. For three substances out of five, the best results were achieved using 5-mm balls. Thermal characteristics showed the good stability of excipients under optimized milling conditions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Powder Technology

ISSN

0921-8831

e-ISSN

1568-5527

Svazek periodika

33

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

103881

Kód UT WoS článku

000892295100007

EID výsledku v databázi Scopus

2-s2.0-85142135929