Revealing Connectivity Patterns of Deep Brain Stimulation Efficacy in Parkinson’s Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F24%3A00602309" target="_blank" >RIV/67985807:_____/24:00602309 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/24:00138461 RIV/00159816:_____/24:00081262 RIV/00023752:_____/24:43921414

Výsledek na webu

<a href="https://doi.org/10.1038/s41598-024-80630-9" target="_blank" >https://doi.org/10.1038/s41598-024-80630-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-024-80630-9" target="_blank" >10.1038/s41598-024-80630-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Revealing Connectivity Patterns of Deep Brain Stimulation Efficacy in Parkinson’s Disease

Popis výsledku v původním jazyce

The aim of this work was to study the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on the subnetwork of subcortical and cortical motor regions using the functional connectivity analysis in Parkinson’s disease (PD). The high-density source space EEG was acquired and analyzed in 43 PD subjects in DBS on and DBS off stimulation states (off medication) during a cognitive-motor task. Increased connectivity within subcortical regions and between subcortical and cortical motor regions in the high gamma band (50-100Hz) was significantly associated with the Movement Disorders Society – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III improvement. Further, the whole brain connectivity patterns were evaluated to complement this finding. The connectivity patterns in low gamma (30-50Hz) and high gamma band (50-100Hz) significantly correlated with the movement improvement. Neural correlates of cognitive performance were detected in the beta (12-30Hz) and high gamma (50-100Hz) bands. Finally, a whole brain multifrequency connectivity profile was found to classify optimal and suboptimal responders to DBS with a positive predictive value of 0.77, negative predictive value of 0.55, specificity of 0.73, and sensitivity of 0.60. Specific connectivity patterns related to motor symptoms improvement after DBS and therapy responsiveness predictive connectivity profiles were uncovered.

Název v anglickém jazyce

Revealing Connectivity Patterns of Deep Brain Stimulation Efficacy in Parkinson’s Disease

Popis výsledku anglicky

The aim of this work was to study the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on the subnetwork of subcortical and cortical motor regions using the functional connectivity analysis in Parkinson’s disease (PD). The high-density source space EEG was acquired and analyzed in 43 PD subjects in DBS on and DBS off stimulation states (off medication) during a cognitive-motor task. Increased connectivity within subcortical regions and between subcortical and cortical motor regions in the high gamma band (50-100Hz) was significantly associated with the Movement Disorders Society – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III improvement. Further, the whole brain connectivity patterns were evaluated to complement this finding. The connectivity patterns in low gamma (30-50Hz) and high gamma band (50-100Hz) significantly correlated with the movement improvement. Neural correlates of cognitive performance were detected in the beta (12-30Hz) and high gamma (50-100Hz) bands. Finally, a whole brain multifrequency connectivity profile was found to classify optimal and suboptimal responders to DBS with a positive predictive value of 0.77, negative predictive value of 0.55, specificity of 0.73, and sensitivity of 0.60. Specific connectivity patterns related to motor symptoms improvement after DBS and therapy responsiveness predictive connectivity profiles were uncovered.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

14

Číslo periodika v rámci svazku

30 December

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

31652

Kód UT WoS článku

001389341300023

EID výsledku v databázi Scopus

2-s2.0-85213719845