Microstate in rats' EEG: a proof of concept study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F25%3A00643765" target="_blank" >RIV/67985807:_____/25:00643765 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/25:43921615 RIV/68407700:21230/25:00386549 RIV/68407700:21460/25:00386549 RIV/00216208:11120/25:43929081

Výsledek na webu

<a href="https://doi.org/10.1038/s41398-025-03702-y" target="_blank" >https://doi.org/10.1038/s41398-025-03702-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41398-025-03702-y" target="_blank" >10.1038/s41398-025-03702-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microstate in rats' EEG: a proof of concept study

Popis výsledku v původním jazyce

The electroencephalogram (EEG) reflecting brain activity may be characterised through brief periods of stable neural activity patterns that recur over time and are referred to as microstates. Microstates are related to a range of cognitive processes, and their analysis has become an increasingly popular tool for studying human brain function. While microstates have been extensively studied in humans, their presence and characteristics in animal models have yet to be as thoroughly investigated. This study aims to address this gap by detecting and characterising microstates in EEGs of rats collected using a superficial electrode system corresponding to homological areas of the human 10–20 system. Specifically, we demonstrate the presence of microstates in rats’ EEGs, i.e., those that may be captured by the same metrics as in humans. We identified five microstate EEG maps in rats, explaining 71% of the variance in our dataset (N = 30). The explained variance, mean temporal coverage values (0.2), and average duration (0.26 s) are comparable to the human-derived EEG microstates. Via a source localisation technique, the cingulate cortex, precuneus, and insula were found to be associated with the microstates’ temporal dynamics. Among the microstates that showed a broadband character, we also found those that showed an association with the theta and alpha bands. These findings have important implications for the use of microstates as a preclinical tool for investigating brain functions, detecting new biomarkers of brain diseases, and translating this knowledge to humans.

Název v anglickém jazyce

Microstate in rats' EEG: a proof of concept study

Popis výsledku anglicky

The electroencephalogram (EEG) reflecting brain activity may be characterised through brief periods of stable neural activity patterns that recur over time and are referred to as microstates. Microstates are related to a range of cognitive processes, and their analysis has become an increasingly popular tool for studying human brain function. While microstates have been extensively studied in humans, their presence and characteristics in animal models have yet to be as thoroughly investigated. This study aims to address this gap by detecting and characterising microstates in EEGs of rats collected using a superficial electrode system corresponding to homological areas of the human 10–20 system. Specifically, we demonstrate the presence of microstates in rats’ EEGs, i.e., those that may be captured by the same metrics as in humans. We identified five microstate EEG maps in rats, explaining 71% of the variance in our dataset (N = 30). The explained variance, mean temporal coverage values (0.2), and average duration (0.26 s) are comparable to the human-derived EEG microstates. Via a source localisation technique, the cingulate cortex, precuneus, and insula were found to be associated with the microstates’ temporal dynamics. Among the microstates that showed a broadband character, we also found those that showed an association with the theta and alpha bands. These findings have important implications for the use of microstates as a preclinical tool for investigating brain functions, detecting new biomarkers of brain diseases, and translating this knowledge to humans.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Translational Psychiatry

ISSN

2158-3188

e-ISSN

2158-3188

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

494

Kód UT WoS článku

001621098500001

EID výsledku v databázi Scopus

2-s2.0-105022654359