A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010201" target="_blank" >RIV/67985823:_____/01:20010201 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture.

Popis výsledku v původním jazyce

We examined the impact of gender of rat donors on the degree of hyperplastic and hypertrophic responses of vascular smooth muscle cells (VSMC) in cultures subjected to repeated passaging. At pasages 40-45, the hyperplastic response, monitored by doublingtime and BrdU-revealed DNA synthesis, was more intense in VSMC of male origin. Female VSMC reacted by more prominent hypertrophic changes, including increase in the volume and protein content as well as polyploidization. In addition, these cells were more effective in adhesion to the growth support (wider spreading, higher content and organization of alpha v integrin and vinculin molecules). The lower responsiveness of female-derived cells to growth stimuli may contribute to less frequent formation ofhyperplastic vascular lesions in female organisms.

Název v anglickém jazyce

A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture.

Popis výsledku anglicky

We examined the impact of gender of rat donors on the degree of hyperplastic and hypertrophic responses of vascular smooth muscle cells (VSMC) in cultures subjected to repeated passaging. At pasages 40-45, the hyperplastic response, monitored by doublingtime and BrdU-revealed DNA synthesis, was more intense in VSMC of male origin. Female VSMC reacted by more prominent hypertrophic changes, including increase in the volume and protein content as well as polyploidization. In addition, these cells were more effective in adhesion to the growth support (wider spreading, higher content and organization of alpha v integrin and vinculin molecules). The lower responsiveness of female-derived cells to growth stimuli may contribute to less frequent formation ofhyperplastic vascular lesions in female organisms.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/IAA7011908" target="_blank" >IAA7011908: Zvýšení adhesní schopnosti buněk povrchovými modifikacemi polymerních nosičů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Histology and Histopathology

ISSN

0213-3911

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

10

Strana od-do

675-684

Kód UT WoS článku

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EID výsledku v databázi Scopus

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