Body, heart, thyroid gland and skeletal muscle weight changes in rats with altered thyroid status.

Kód výsledku v IS VaVaI

RIV/67985823:_____/01:20010264 - isvavai.cz

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Body, heart, thyroid gland and skeletal muscle weight changes in rats with altered thyroid status.

Popis výsledku v původním jazyce

In the present paper we describe in inbred Lewis strain rats changes of anatomical parameters - body weight, body weight gain per week, absolute and relative heart, thyroid gland and skeletal muscle weights that are assumed to reflect experimentally altered thyroid status. The hyperthyroid state was induced by DL-thyroxine or Na 3,3',5-triiodo-L-thyronine, while methimazole was employed for inducing hypothyroidism. We have found that when compared to euthyroid rats, hypothyroidism resulted in a significantly lower body weight gain, absolute and relative heart weight and, in contrast, in a significant increase of absolute and relative thyroid gland weight. On the other hand, hyperthyroidism led to a significant increase of absolute and relative heart weight and to a significant reduction of absolute and relative thyroid gland weight. However, the body mass was not significantly altered in hyperthyroidism as compared with euthyroid rats. We conclude that our protocol leads to chronic hyp

Název v anglickém jazyce

Body, heart, thyroid gland and skeletal muscle weight changes in rats with altered thyroid status.

Popis výsledku anglicky

In the present paper we describe in inbred Lewis strain rats changes of anatomical parameters - body weight, body weight gain per week, absolute and relative heart, thyroid gland and skeletal muscle weights that are assumed to reflect experimentally altered thyroid status. The hyperthyroid state was induced by DL-thyroxine or Na 3,3',5-triiodo-L-thyronine, while methimazole was employed for inducing hypothyroidism. We have found that when compared to euthyroid rats, hypothyroidism resulted in a significantly lower body weight gain, absolute and relative heart weight and, in contrast, in a significant increase of absolute and relative thyroid gland weight. On the other hand, hyperthyroidism led to a significant increase of absolute and relative heart weight and to a significant reduction of absolute and relative thyroid gland weight. However, the body mass was not significantly altered in hyperthyroidism as compared with euthyroid rats. We conclude that our protocol leads to chronic hyp

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

GA304/00/1653: Regulace exprese fenotypu svalových vláken hormony štítné žlázy

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

50

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

619-626

Kód UT WoS článku

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EID výsledku v databázi Scopus

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