Vliv chronicky změněného tyroidního stavu na aktivitu jaterní mitochondriální glycerol-3-fosfát dehydrogenázy u samic potkana inbredního kmene Lewis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F04%3A00102567" target="_blank" >RIV/67985823:_____/04:00102567 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of chronically altered thyroid status on the activity of liver mitochondrial glycerol-3-phosphate dehydrogenase in female inbred Lewis rats

Popis výsledku v původním jazyce

The aim of this study was to ascertain whether GPDH activity could be used as an index of thyroid status during chronic experiments over several months. We therefore analyzed GPDH activity in liver mitochondria of female inbred Lewis rats with thyroid status altered for 2 to 12 months. Hyperthyroid state was maintained by triiodothyronine (T3) or thyroxine (T4) administration, while methimazole was employed for inducing hypothyroidism. We found a seven- and three-fold increase of GPDH activity in femalerats after T3 and T4 administration, respectively, compader to euthyroid females, whereas administration of methimazole reduced the enzyme activity almost to one-third of the euthyroid values. We conclude that the level of the rat liver GPDH activity could serve as a useful marker for evaluation of hyperthyroid and hypothyroid status in chronic long-lasting experiments on female inbred Lewis rats

Název v anglickém jazyce

Influence of chronically altered thyroid status on the activity of liver mitochondrial glycerol-3-phosphate dehydrogenase in female inbred Lewis rats

Popis výsledku anglicky

The aim of this study was to ascertain whether GPDH activity could be used as an index of thyroid status during chronic experiments over several months. We therefore analyzed GPDH activity in liver mitochondria of female inbred Lewis rats with thyroid status altered for 2 to 12 months. Hyperthyroid state was maintained by triiodothyronine (T3) or thyroxine (T4) administration, while methimazole was employed for inducing hypothyroidism. We found a seven- and three-fold increase of GPDH activity in femalerats after T3 and T4 administration, respectively, compader to euthyroid females, whereas administration of methimazole reduced the enzyme activity almost to one-third of the euthyroid values. We conclude that the level of the rat liver GPDH activity could serve as a useful marker for evaluation of hyperthyroid and hypothyroid status in chronic long-lasting experiments on female inbred Lewis rats

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA304%2F00%2F1653" target="_blank" >GA304/00/1653: Regulace exprese fenotypu svalových vláken hormony štítné žlázy</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hormone and Metabolic Research

ISSN

0018-5043

e-ISSN

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Svazek periodika

36

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

286-290

Kód UT WoS článku

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EID výsledku v databázi Scopus

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