Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00435667" target="_blank" >RIV/67985823:_____/14:00435667 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11745-014-3948-x" target="_blank" >http://dx.doi.org/10.1007/s11745-014-3948-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11745-014-3948-x" target="_blank" >10.1007/s11745-014-3948-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids

Popis výsledku v původním jazyce

We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activatedreceptor (PPAR)-? target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders

Název v anglickém jazyce

Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids

Popis výsledku anglicky

We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activatedreceptor (PPAR)-? target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/GA13-00871S" target="_blank" >GA13-00871S: Zvýšení energetického výdeje v tukové tkáni kombinovaným působením n-3 mastných kyselin, resveratrolu a kalorické restrikce</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Lipids

ISSN

0024-4201

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1081-1089

Kód UT WoS článku

000344151800001

EID výsledku v databázi Scopus

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