Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00475001" target="_blank" >RIV/67985823:_____/17:00475001 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.neulet.2017.02.043" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2017.02.043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2017.02.043" target="_blank" >10.1016/j.neulet.2017.02.043</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?

Popis výsledku v původním jazyce

Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats. In addition to SE group four other groups were formed: naive animals without any injection, lithium chloride group, paraldehyde group and lithium-paraldehyde group. Cortical epileptic afterdischarges (CxADs) induced by increasing intensities of stimulation current were used as a measure of excitability. SE animals did not exhibit any change in duration of CxADs with increasing stimulation intensity in contrast to na ve control with a progressive prolongation of CxAD. LiCI group was similar to SE rats whereas paraldehyde and lithium-paraldehyde groups exhibited some progress in duration of ADs. Lithium chloride participates in short-term changes of CxADs after SE. Paraldehyde and combination of lithium paraldehyde are similar to na ve controls.

Název v anglickém jazyce

Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?

Popis výsledku anglicky

Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats. In addition to SE group four other groups were formed: naive animals without any injection, lithium chloride group, paraldehyde group and lithium-paraldehyde group. Cortical epileptic afterdischarges (CxADs) induced by increasing intensities of stimulation current were used as a measure of excitability. SE animals did not exhibit any change in duration of CxADs with increasing stimulation intensity in contrast to na ve control with a progressive prolongation of CxAD. LiCI group was similar to SE rats whereas paraldehyde and lithium-paraldehyde groups exhibited some progress in duration of ADs. Lithium chloride participates in short-term changes of CxADs after SE. Paraldehyde and combination of lithium paraldehyde are similar to na ve controls.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience Letters

ISSN

0304-3940

e-ISSN

—

Svazek periodika

644

Číslo periodika v rámci svazku

Mar 22

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

4

Strana od-do

1-4

Kód UT WoS článku

000407529300001

EID výsledku v databázi Scopus

2-s2.0-85013790767