Sex Differences in Cardiac Ischemia/Reperfusion Injury

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00537904" target="_blank" >RIV/67985823:_____/20:00537904 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023884:_____/20:00008827

Výsledek na webu

<a href="https://doi.org/10.1007/978-3-030-58677-5_2" target="_blank" >https://doi.org/10.1007/978-3-030-58677-5_2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-030-58677-5_2" target="_blank" >10.1007/978-3-030-58677-5_2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sex Differences in Cardiac Ischemia/Reperfusion Injury

Popis výsledku v původním jazyce

I tis now well known that differences in the structure and function of the heart exist between male and female hearts. Several lines of exerimental and clinical investigations have reported that there are sex differences in the tolerance to myocardial ischemia, whereby adult male hearts are more susceptible to ischemia/reperfusion (I/R) injury as compared to pre-menopausal female hearts. Experimental studies have also shown that adult female hearts have increased resistence and male hearts are more susceptible to I/R in animal exposed to perinatal hypoxia. Although there is now a large body of evidence which indicates that estrogen is involved in the sex differences with respect to cardiac tolerance to ischemia, the exact mechanisms involved in the cardiac response to ischemia or hypoxia are not fully understood. Accordingly, this chapter is intended to describe some of the known molecular nad cellular mechanisms that contribute to sex differences in the susceptibility to I/R injury. With such a new basic information and advancements in the understanding of the mechanisms responsible for sex differences in cardiac sensitivity to ischemic injury, it is hoped that some specific therapeutic strategies will be developed for post-menopausal females for better quality of life, and lower mortality.

Název v anglickém jazyce

Sex Differences in Cardiac Ischemia/Reperfusion Injury

Popis výsledku anglicky

I tis now well known that differences in the structure and function of the heart exist between male and female hearts. Several lines of exerimental and clinical investigations have reported that there are sex differences in the tolerance to myocardial ischemia, whereby adult male hearts are more susceptible to ischemia/reperfusion (I/R) injury as compared to pre-menopausal female hearts. Experimental studies have also shown that adult female hearts have increased resistence and male hearts are more susceptible to I/R in animal exposed to perinatal hypoxia. Although there is now a large body of evidence which indicates that estrogen is involved in the sex differences with respect to cardiac tolerance to ischemia, the exact mechanisms involved in the cardiac response to ischemia or hypoxia are not fully understood. Accordingly, this chapter is intended to describe some of the known molecular nad cellular mechanisms that contribute to sex differences in the susceptibility to I/R injury. With such a new basic information and advancements in the understanding of the mechanisms responsible for sex differences in cardiac sensitivity to ischemic injury, it is hoped that some specific therapeutic strategies will be developed for post-menopausal females for better quality of life, and lower mortality.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/GA18-03207S" target="_blank" >GA18-03207S: Vliv exprese lidského C-reaktivního proteinu na ischemickou toleranci srdce spontánně hypertenzních potkanů.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Sex Differences in Heart Disease

ISBN

978-3-030-58676-8

Počet stran výsledku

13

Strana od-do

25-37

Počet stran knihy

284

Název nakladatele

Springer International Publishing

Místo vydání

Cham

Kód UT WoS kapitoly

—