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Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00541688" target="_blank" >RIV/67985823:_____/21:00541688 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/21:10427448 RIV/00023001:_____/21:00080663

  • Výsledek na webu

    <a href="https://doi.org/10.1139/cjpp-2020-0310" target="_blank" >https://doi.org/10.1139/cjpp-2020-0310</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1139/cjpp-2020-0310" target="_blank" >10.1139/cjpp-2020-0310</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults

  • Popis výsledku v původním jazyce

    Epidemiological studies have demonstrated a relationship between the adverse influence of perinatal development and increased risk of ischemic heart disease in adults. From negative factors to which the fetus is subjected, the most important is hypoxia. The fetus may experience hypoxic stress under different conditions, including pregnancy at high altitude, pregnancy with anemia, placental insufficiency, and heart, lung, and kidney disease. One of the most common insults during the early stages of postnatal development is hypoxemia due to congenital cyanotic heart defects. Experimental studies have demonstrated a link between early hypoxia and increased risk of ischemia/reperfusion injury (I/R) in adults. Furthermore, it has been observed that late myocardial effects of chronic hypoxia, experienced in early life, may be sex-dependent. Unlike in males, perinatal hypoxia significantly increased cardiac tolerance to acute I/R injury in adult females, expressed as decreased infarct size and lower incidence of ischemic arrhythmias. It was suggested that early hypoxia may result in sex-dependent programming of specific genes in the offspring with the consequence of increased cardiac susceptibility to I/R injury in adult males. These results would have important clinical implications, since cardiac sensitivity to oxygen deprivation in adult patients may be significantly influenced by perinatal hypoxia in a sex-dependent manner.

  • Název v anglickém jazyce

    Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults

  • Popis výsledku anglicky

    Epidemiological studies have demonstrated a relationship between the adverse influence of perinatal development and increased risk of ischemic heart disease in adults. From negative factors to which the fetus is subjected, the most important is hypoxia. The fetus may experience hypoxic stress under different conditions, including pregnancy at high altitude, pregnancy with anemia, placental insufficiency, and heart, lung, and kidney disease. One of the most common insults during the early stages of postnatal development is hypoxemia due to congenital cyanotic heart defects. Experimental studies have demonstrated a link between early hypoxia and increased risk of ischemia/reperfusion injury (I/R) in adults. Furthermore, it has been observed that late myocardial effects of chronic hypoxia, experienced in early life, may be sex-dependent. Unlike in males, perinatal hypoxia significantly increased cardiac tolerance to acute I/R injury in adult females, expressed as decreased infarct size and lower incidence of ischemic arrhythmias. It was suggested that early hypoxia may result in sex-dependent programming of specific genes in the offspring with the consequence of increased cardiac susceptibility to I/R injury in adult males. These results would have important clinical implications, since cardiac sensitivity to oxygen deprivation in adult patients may be significantly influenced by perinatal hypoxia in a sex-dependent manner.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30105 - Physiology (including cytology)

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Canadian Journal of Physiology and Pharmacology

  • ISSN

    0008-4212

  • e-ISSN

    1205-7541

  • Svazek periodika

    99

  • Číslo periodika v rámci svazku

    1

  • Stát vydavatele periodika

    CA - Kanada

  • Počet stran výsledku

    8

  • Strana od-do

    1-8

  • Kód UT WoS článku

    000613249900001

  • EID výsledku v databázi Scopus

    2-s2.0-85099853569