Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00541688" target="_blank" >RIV/67985823:_____/21:00541688 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/21:10427448 RIV/00023001:_____/21:00080663
Výsledek na webu
<a href="https://doi.org/10.1139/cjpp-2020-0310" target="_blank" >https://doi.org/10.1139/cjpp-2020-0310</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1139/cjpp-2020-0310" target="_blank" >10.1139/cjpp-2020-0310</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults
Popis výsledku v původním jazyce
Epidemiological studies have demonstrated a relationship between the adverse influence of perinatal development and increased risk of ischemic heart disease in adults. From negative factors to which the fetus is subjected, the most important is hypoxia. The fetus may experience hypoxic stress under different conditions, including pregnancy at high altitude, pregnancy with anemia, placental insufficiency, and heart, lung, and kidney disease. One of the most common insults during the early stages of postnatal development is hypoxemia due to congenital cyanotic heart defects. Experimental studies have demonstrated a link between early hypoxia and increased risk of ischemia/reperfusion injury (I/R) in adults. Furthermore, it has been observed that late myocardial effects of chronic hypoxia, experienced in early life, may be sex-dependent. Unlike in males, perinatal hypoxia significantly increased cardiac tolerance to acute I/R injury in adult females, expressed as decreased infarct size and lower incidence of ischemic arrhythmias. It was suggested that early hypoxia may result in sex-dependent programming of specific genes in the offspring with the consequence of increased cardiac susceptibility to I/R injury in adult males. These results would have important clinical implications, since cardiac sensitivity to oxygen deprivation in adult patients may be significantly influenced by perinatal hypoxia in a sex-dependent manner.
Název v anglickém jazyce
Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults
Popis výsledku anglicky
Epidemiological studies have demonstrated a relationship between the adverse influence of perinatal development and increased risk of ischemic heart disease in adults. From negative factors to which the fetus is subjected, the most important is hypoxia. The fetus may experience hypoxic stress under different conditions, including pregnancy at high altitude, pregnancy with anemia, placental insufficiency, and heart, lung, and kidney disease. One of the most common insults during the early stages of postnatal development is hypoxemia due to congenital cyanotic heart defects. Experimental studies have demonstrated a link between early hypoxia and increased risk of ischemia/reperfusion injury (I/R) in adults. Furthermore, it has been observed that late myocardial effects of chronic hypoxia, experienced in early life, may be sex-dependent. Unlike in males, perinatal hypoxia significantly increased cardiac tolerance to acute I/R injury in adult females, expressed as decreased infarct size and lower incidence of ischemic arrhythmias. It was suggested that early hypoxia may result in sex-dependent programming of specific genes in the offspring with the consequence of increased cardiac susceptibility to I/R injury in adult males. These results would have important clinical implications, since cardiac sensitivity to oxygen deprivation in adult patients may be significantly influenced by perinatal hypoxia in a sex-dependent manner.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30105 - Physiology (including cytology)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Canadian Journal of Physiology and Pharmacology
ISSN
0008-4212
e-ISSN
1205-7541
Svazek periodika
99
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
CA - Kanada
Počet stran výsledku
8
Strana od-do
1-8
Kód UT WoS článku
000613249900001
EID výsledku v databázi Scopus
2-s2.0-85099853569