Cardiac Mitochondria and Ischemia/Reperfusion Injury-Sex Differences

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00537912" target="_blank" >RIV/67985823:_____/20:00537912 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/978-3-030-58677-5_15" target="_blank" >https://doi.org/10.1007/978-3-030-58677-5_15</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-030-58677-5_15" target="_blank" >10.1007/978-3-030-58677-5_15</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiac Mitochondria and Ischemia/Reperfusion Injury-Sex Differences

Popis výsledku v původním jazyce

It is now widely accepted that function of cardiac mitochondria is sex-dependent. Female mitochondria better utilize lipids and exhibit higher oxidative capacity in comparison with males. Our results have revealed that female cardiac mitochondria are more resistant to calcium-induced swelling as compared with the male myocardium, this suggests their better protection against mitochodrial permeability transition pore (PTP) opening.It seems to us that sex-dependent specificity of the PTP function is not the results of differences in its protein composition, since the male and female rat heart contains comparable amount of ATP synthase and its regulatory protein cyclophilinD (CypD). The higher hypoxic tolerance of the female cardiac mitochondria thus rather reflects sex differences in the regulation of PTP function, probably together with regulation of CypD by post-translational modifications. The precise knowledge of the composition of the PTP compex and regulation of pore opening are essential conditions for the development of new drugs targeting the function of PTP.

Název v anglickém jazyce

Cardiac Mitochondria and Ischemia/Reperfusion Injury-Sex Differences

Popis výsledku anglicky

It is now widely accepted that function of cardiac mitochondria is sex-dependent. Female mitochondria better utilize lipids and exhibit higher oxidative capacity in comparison with males. Our results have revealed that female cardiac mitochondria are more resistant to calcium-induced swelling as compared with the male myocardium, this suggests their better protection against mitochodrial permeability transition pore (PTP) opening.It seems to us that sex-dependent specificity of the PTP function is not the results of differences in its protein composition, since the male and female rat heart contains comparable amount of ATP synthase and its regulatory protein cyclophilinD (CypD). The higher hypoxic tolerance of the female cardiac mitochondria thus rather reflects sex differences in the regulation of PTP function, probably together with regulation of CypD by post-translational modifications. The precise knowledge of the composition of the PTP compex and regulation of pore opening are essential conditions for the development of new drugs targeting the function of PTP.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

<a href="/cs/project/GJ19-04790Y" target="_blank" >GJ19-04790Y: Efekt perinatální hypoxie a nízkoproteinové diety na úlohu RNA-demetylázy FTO v regulaci srdeční funkce a energetického metabolismu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Sex Differences in Heart Disease

ISBN

978-3-030-58676-8

Počet stran výsledku

9

Strana od-do

257-265

Počet stran knihy

284

Název nakladatele

Springer International Publishing

Místo vydání

Cham

Kód UT WoS kapitoly

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