A simple neuronal model with intrinsic saturation of the firing frequency

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F22%3A00564043" target="_blank" >RIV/67985823:_____/22:00564043 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/22:10449324

Výsledek na webu

<a href="https://doi.org/10.1016/j.biosystems.2022.104780" target="_blank" >https://doi.org/10.1016/j.biosystems.2022.104780</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biosystems.2022.104780" target="_blank" >10.1016/j.biosystems.2022.104780</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A simple neuronal model with intrinsic saturation of the firing frequency

Popis výsledku v původním jazyce

We present a comparison of the intrinsic saturation of firing frequency in four simple neural models: leaky integrate-and-fire model, leaky integrate-and-fire model with reversal potentials, two-point leaky integrate-and-fire model, and a two-point leaky integrate-and-fire model with reversal potentials. “Two-point”means that the equivalent circuit has two nodes (dendritic and somatic) instead of one (somatic only). The results suggest that the reversal potential increases the slope of the “firing rate vs input”curve due to a smaller effective membrane time constant, but does not necessarily induce saturation of the firing rate. The two-point model without the reversal potential does not limit the voltage or the firing rate. In contrast to the previous models, the two-point model with the reversal potential limits the asymptotic voltage and the firing rate, which is the main result of this paper. The case of excitatory inputs is considered first and followed by the case of both excitatory and inhibitory inputs.

Název v anglickém jazyce

A simple neuronal model with intrinsic saturation of the firing frequency

Popis výsledku anglicky

We present a comparison of the intrinsic saturation of firing frequency in four simple neural models: leaky integrate-and-fire model, leaky integrate-and-fire model with reversal potentials, two-point leaky integrate-and-fire model, and a two-point leaky integrate-and-fire model with reversal potentials. “Two-point”means that the equivalent circuit has two nodes (dendritic and somatic) instead of one (somatic only). The results suggest that the reversal potential increases the slope of the “firing rate vs input”curve due to a smaller effective membrane time constant, but does not necessarily induce saturation of the firing rate. The two-point model without the reversal potential does not limit the voltage or the firing rate. In contrast to the previous models, the two-point model with the reversal potential limits the asymptotic voltage and the firing rate, which is the main result of this paper. The case of excitatory inputs is considered first and followed by the case of both excitatory and inhibitory inputs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10103 - Statistics and probability

Projekt

<a href="/cs/project/GA20-10251S" target="_blank" >GA20-10251S: Optimalita neuronální komunikace: informačně-teoretický pohled</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biosystems

ISSN

0303-2647

e-ISSN

1872-8324

Svazek periodika

222

Číslo periodika v rámci svazku

Dec

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

104780

Kód UT WoS článku

000879545500001

EID výsledku v databázi Scopus

2-s2.0-85140048255