Current analytical methods to monitor type 2 diabetes medication in biological samples

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00570364" target="_blank" >RIV/67985823:_____/23:00570364 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/23:43927221

Výsledek na webu

<a href="https://doi.org/10.1016/j.trac.2022.116831" target="_blank" >https://doi.org/10.1016/j.trac.2022.116831</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.trac.2022.116831" target="_blank" >10.1016/j.trac.2022.116831</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Current analytical methods to monitor type 2 diabetes medication in biological samples

Popis výsledku v původním jazyce

We review the current analytical methods for analyzing type 2 diabetes (T2D) medication in human and animal samples. We discuss the advantages and limitations during sample preparation, separation, and detection of these drugs. Finally, we highlight the parameters to be considered for multi-targeted analytical methods and for assessing T2D medication adherence. By reviewing over 140 original papers, we can conclude that current analytical methods for T2D drug analysis involve: (1) extraction using protein precipitation with acetonitrile or methanol, (2) reversed-phase liquid chromatography separation using octadecyl (C18)-based columns with analysis time <20 min, and (3) electrospray ionization in positive ion mode with a triple quadrupole or quadrupole/linear ion trap mass analyzer. Methods for screening antidiabetics were limited to 1–5 analytes, far less than in other areas, such as analysis of cardiovascular agents, anticancer drugs, or drug screening for forensic services.

Název v anglickém jazyce

Current analytical methods to monitor type 2 diabetes medication in biological samples

Popis výsledku anglicky

We review the current analytical methods for analyzing type 2 diabetes (T2D) medication in human and animal samples. We discuss the advantages and limitations during sample preparation, separation, and detection of these drugs. Finally, we highlight the parameters to be considered for multi-targeted analytical methods and for assessing T2D medication adherence. By reviewing over 140 original papers, we can conclude that current analytical methods for T2D drug analysis involve: (1) extraction using protein precipitation with acetonitrile or methanol, (2) reversed-phase liquid chromatography separation using octadecyl (C18)-based columns with analysis time <20 min, and (3) electrospray ionization in positive ion mode with a triple quadrupole or quadrupole/linear ion trap mass analyzer. Methods for screening antidiabetics were limited to 1–5 analytes, far less than in other areas, such as analysis of cardiovascular agents, anticancer drugs, or drug screening for forensic services.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

TrAC-Trends in Analytical Chemistry

ISSN

0165-9936

e-ISSN

1879-3142

Svazek periodika

158

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

21

Strana od-do

116831

Kód UT WoS článku

001006481500001

EID výsledku v databázi Scopus

2-s2.0-85142506024