Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00570504" target="_blank" >RIV/67985823:_____/23:00570504 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21220/23:00371932 RIV/00216224:14740/23:00133612 RIV/00216208:11130/23:10457945 RIV/00216208:11110/23:10457945 a 2 dalších

Výsledek na webu

<a href="https://doi.org/10.1093/micmic/ozac012" target="_blank" >https://doi.org/10.1093/micmic/ozac012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/micmic/ozac012" target="_blank" >10.1093/micmic/ozac012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue

Popis výsledku v původním jazyce

Talipes equinovarus congenitus (clubfoot) is frequently defined as a stiff, contracted deformity, but few studies have described the tissue from the point of view of the extracellular matrix, and none have quantified its mechanical properties. Several researchers have observed that clubfoot exhibits signs of fibrosis in the medial side of the deformity that are absent in the lateral side. Our study aims to quantify the differences between the medial and lateral side tissue obtained from relapsed clubfoot during surgery in terms of the morphological and mechanical properties of the tissue. Combining methods of optical and atomic force microscopy, our study revealed that the medial side has a higher Young’s modulus, contains more collagen and less adipose tissue and that the collagen fibers propagate at a higher frequency of the crimp pattern after surgical dissection of the tissue. Our study offers a multi-correlative approach that thoroughly investigates the relapsed clubfoot tissue.

Název v anglickém jazyce

Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue

Popis výsledku anglicky

Talipes equinovarus congenitus (clubfoot) is frequently defined as a stiff, contracted deformity, but few studies have described the tissue from the point of view of the extracellular matrix, and none have quantified its mechanical properties. Several researchers have observed that clubfoot exhibits signs of fibrosis in the medial side of the deformity that are absent in the lateral side. Our study aims to quantify the differences between the medial and lateral side tissue obtained from relapsed clubfoot during surgery in terms of the morphological and mechanical properties of the tissue. Combining methods of optical and atomic force microscopy, our study revealed that the medial side has a higher Young’s modulus, contains more collagen and less adipose tissue and that the collagen fibers propagate at a higher frequency of the crimp pattern after surgical dissection of the tissue. Our study offers a multi-correlative approach that thoroughly investigates the relapsed clubfoot tissue.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30211 - Orthopaedics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microscopy and Microanalysis

ISSN

1431-9276

e-ISSN

1435-8115

Svazek periodika

29

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

265-272

Kód UT WoS článku

001033590800026

EID výsledku v databázi Scopus

2-s2.0-85153729727