Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00583345" target="_blank" >RIV/67985823:_____/24:00583345 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/24:00583345 RIV/00216208:11130/24:10475576 RIV/46747885:24510/24:00012334 RIV/00216208:11120/24:43926622 a 2 dalších

Výsledek na webu

<a href="https://doi.org/10.1016/j.jss.2023.12.043" target="_blank" >https://doi.org/10.1016/j.jss.2023.12.043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jss.2023.12.043" target="_blank" >10.1016/j.jss.2023.12.043</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review

Popis výsledku v původním jazyce

Burn injuries are a significant global health concern, with more than 11 million people requiring medical intervention each year and approximately 180,000 deaths annually. Despite progress in health and social care, burn injuries continue to result in socioeconomic burdens for victims and their families. The management of severe burn injuries involves preventing and treating burn shock and promoting skin repair through a two-step procedure of covering and closing the wound. Currently, split-thickness/full-thickness skin autografts are the gold standard for permanent skin substitution. However, deep burns treated with split-thickness skin autografts may contract, leading to functional and appearance issues. Conversely, defects treated with full-thickness skin autografts often result in more satisfactory function and appearance. The development of tissue-engineered dermal templates has further expanded the scope of wound repair, providing scar reductive and regenerative properties that have extended their use to reconstructive surgical interventions. Although their interactions with the wound microenvironment are not fully understood, these templates have shown potential in local infection control. This narrative review discusses the current state of wound repair in burn injuries, focusing on the progress made from wound cover to wound closure and local infection control. Advancements in technology and therapies hold promise for improving the outcomes for burn injury patients. Understanding the underlying mechanisms of wound repair and tissue regeneration may provide new insights for developing more effective treatments in the future.

Název v anglickém jazyce

Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review

Popis výsledku anglicky

Burn injuries are a significant global health concern, with more than 11 million people requiring medical intervention each year and approximately 180,000 deaths annually. Despite progress in health and social care, burn injuries continue to result in socioeconomic burdens for victims and their families. The management of severe burn injuries involves preventing and treating burn shock and promoting skin repair through a two-step procedure of covering and closing the wound. Currently, split-thickness/full-thickness skin autografts are the gold standard for permanent skin substitution. However, deep burns treated with split-thickness skin autografts may contract, leading to functional and appearance issues. Conversely, defects treated with full-thickness skin autografts often result in more satisfactory function and appearance. The development of tissue-engineered dermal templates has further expanded the scope of wound repair, providing scar reductive and regenerative properties that have extended their use to reconstructive surgical interventions. Although their interactions with the wound microenvironment are not fully understood, these templates have shown potential in local infection control. This narrative review discusses the current state of wound repair in burn injuries, focusing on the progress made from wound cover to wound closure and local infection control. Advancements in technology and therapies hold promise for improving the outcomes for burn injury patients. Understanding the underlying mechanisms of wound repair and tissue regeneration may provide new insights for developing more effective treatments in the future.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Surgical Research

ISSN

0022-4804

e-ISSN

1095-8673

Svazek periodika

296

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

21

Strana od-do

383-403

Kód UT WoS článku

001182164100001

EID výsledku v databázi Scopus

2-s2.0-85185179580