Optimizing Flow and Segregaton Properties of Lactose/Microcrystalline Cellulose Mixture for Tablet Compression.

Kód výsledku v IS VaVaI

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Výsledek na webu

<a href="http://hdl.handle.net/11104/0270062" target="_blank" >http://hdl.handle.net/11104/0270062</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Optimizing Flow and Segregaton Properties of Lactose/Microcrystalline Cellulose Mixture for Tablet Compression.

Popis výsledku v původním jazyce

The present study deals with optimizing the flow and segregation properties of levocetirizine hydrochloride formulation, where the delay between homogenization and tablet compression was found to affect the tablet content uniformity. In addition to API, the base formulation comprised spray dried lactose monohydrate, milled lactose monohydrate 200 mesh, Avicel PH 101 microcrystalline cellulose, and minor excipients. Several alternative mixtures were prepared using the same total composition, but different grades of lactose and microcrystalline cellulose. These mixtures were then tested for the segregation behavior in an in-house segregation device and the flow properties using the Freeman FT4 powder rheometer. The segregation tests showed the grade of lactose is essential for mixture in-flow segregation. While SD lactose mixtures increased the API content in a direction countercurrent to flow, the milled lactose mixtures segregated API concurrently. Mixtures using both lactose grades showed combined effect, resulting in the least segregation due to the two segregation processes competing with each other. However, the segregation was extremely sensitive to ageing of the mixture. It was also found that each type of lactose causes a different flow regime of the mixture in process vessels. In order to improve the content uniformity of the tablets, it was found the volumetric flow regime of transport to tablet press is required as well as the aggregate formation should be prevented.n

Název v anglickém jazyce

Optimizing Flow and Segregaton Properties of Lactose/Microcrystalline Cellulose Mixture for Tablet Compression.

Popis výsledku anglicky

The present study deals with optimizing the flow and segregation properties of levocetirizine hydrochloride formulation, where the delay between homogenization and tablet compression was found to affect the tablet content uniformity. In addition to API, the base formulation comprised spray dried lactose monohydrate, milled lactose monohydrate 200 mesh, Avicel PH 101 microcrystalline cellulose, and minor excipients. Several alternative mixtures were prepared using the same total composition, but different grades of lactose and microcrystalline cellulose. These mixtures were then tested for the segregation behavior in an in-house segregation device and the flow properties using the Freeman FT4 powder rheometer. The segregation tests showed the grade of lactose is essential for mixture in-flow segregation. While SD lactose mixtures increased the API content in a direction countercurrent to flow, the milled lactose mixtures segregated API concurrently. Mixtures using both lactose grades showed combined effect, resulting in the least segregation due to the two segregation processes competing with each other. However, the segregation was extremely sensitive to ageing of the mixture. It was also found that each type of lactose causes a different flow regime of the mixture in process vessels. In order to improve the content uniformity of the tablets, it was found the volumetric flow regime of transport to tablet press is required as well as the aggregate formation should be prevented.n

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 3rd International Conference on Chemical Technology

ISBN

978-80-86238-82-1

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

478-483

Název nakladatele

Czech Society of Industrial Chemistry

Místo vydání

Prague

Místo konání akce

Mikulov

Datum konání akce

13. 4. 2015

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000383856800092