Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution.
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F21%3A00559341" target="_blank" >RIV/67985858:_____/21:00559341 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60461373:22330/21:43922073 RIV/60461373:22340/21:43922073 RIV/60461373:22810/21:43922073
Výsledek na webu
<a href="https://www.mdpi.com/1999-4923/13/3/412" target="_blank" >https://www.mdpi.com/1999-4923/13/3/412</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/pharmaceutics13030412" target="_blank" >10.3390/pharmaceutics13030412</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution.
Popis výsledku v původním jazyce
Stability studies represent an essential component of pharmaceutical development, enabling critical evaluation of the therapeutic potential of an active pharmaceutical ingredient (API) or a final pharmaceutical product under the influence of various environmental factors. The aim of the present study was to investigate the chemical stability of cannabidiol (CBD) in the form of a solid powder (hereinafter referred to as CBD powder) and also dissolved in sunflower oil. We performed stress studies in accordance with the International Conference on Harmonization (ICH) guidelines, where 5 mg of marketed CBD in the form of a solid powder and in form of oil solution were exposed for 7 and 14, 30, 60, 90, 180, 270, and 365 days to precisely defined temperature and humidity conditions, 25 ◦C ± 2 ◦C/60% RH ± 5% and 40 ◦C ± 2 ◦C/75% RH ± 5% in both open and closed vials in the dark. CBD powder was significantly more stable than CBD in oil solution. Such finding is important because CBD is often administered dissolved in oil matrix in practice due tonvery good bioavailability. Thus, the knowledge on admissible shelf time is of paramount importance.
Název v anglickém jazyce
Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution.
Popis výsledku anglicky
Stability studies represent an essential component of pharmaceutical development, enabling critical evaluation of the therapeutic potential of an active pharmaceutical ingredient (API) or a final pharmaceutical product under the influence of various environmental factors. The aim of the present study was to investigate the chemical stability of cannabidiol (CBD) in the form of a solid powder (hereinafter referred to as CBD powder) and also dissolved in sunflower oil. We performed stress studies in accordance with the International Conference on Harmonization (ICH) guidelines, where 5 mg of marketed CBD in the form of a solid powder and in form of oil solution were exposed for 7 and 14, 30, 60, 90, 180, 270, and 365 days to precisely defined temperature and humidity conditions, 25 ◦C ± 2 ◦C/60% RH ± 5% and 40 ◦C ± 2 ◦C/75% RH ± 5% in both open and closed vials in the dark. CBD powder was significantly more stable than CBD in oil solution. Such finding is important because CBD is often administered dissolved in oil matrix in practice due tonvery good bioavailability. Thus, the knowledge on admissible shelf time is of paramount importance.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
20401 - Chemical engineering (plants, products)
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Pharmaceutics
ISSN
1999-4923
e-ISSN
1999-4923
Svazek periodika
13
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
10
Strana od-do
412
Kód UT WoS článku
000634052400001
EID výsledku v databázi Scopus
2-s2.0-85103095414