Adaptive Synthesis, Supramolecular Behavior, and Biological Properties of Amphiphilic Carbosilane-Phosphonium Dendrons with Tunable Structure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F24%3A00600878" target="_blank" >RIV/67985858:_____/24:00600878 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/25:00564081 RIV/44555601:13440/24:43898635 RIV/00179906:_____/24:10489275

Výsledek na webu

<a href="https://pubs.acs.org/doi/epdf/10.1021/acs.biomac.4c01092?ref=article_openPDF" target="_blank" >https://pubs.acs.org/doi/epdf/10.1021/acs.biomac.4c01092?ref=article_openPDF</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.biomac.4c01092" target="_blank" >10.1021/acs.biomac.4c01092</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adaptive Synthesis, Supramolecular Behavior, and Biological Properties of Amphiphilic Carbosilane-Phosphonium Dendrons with Tunable Structure

Popis výsledku v původním jazyce

Here, we present a modular synthesis as well as physicochemical and biological evaluation of a new series of ampiphilic and hydrophilic domains are systematically varied, changing the dendron shape from cylindrical to conical. In physiological solution, the dendrons exhibit very low critical micelle concentrations (2.6−4.9 μM) and form stable and uniform micelles 6−12 nm in diameter, depending on dendron shape. The results correlate well with molecular dynamics simulations. The compounds show relatively high cytotoxicity (IC50 1.2−21.0 μM) associated with micelle formation and inversely related to the size of assembled particles. Depending on their shape, the dendrons show promising results in terms of dendriplex formation and antibacterial activity. In addition to simple amphiphilic dendrons, a fluorescently labeled analogue was also prepared and utilized as an additive visualizingnthe dendron’s cellular uptake.

Název v anglickém jazyce

Adaptive Synthesis, Supramolecular Behavior, and Biological Properties of Amphiphilic Carbosilane-Phosphonium Dendrons with Tunable Structure

Popis výsledku anglicky

Here, we present a modular synthesis as well as physicochemical and biological evaluation of a new series of ampiphilic and hydrophilic domains are systematically varied, changing the dendron shape from cylindrical to conical. In physiological solution, the dendrons exhibit very low critical micelle concentrations (2.6−4.9 μM) and form stable and uniform micelles 6−12 nm in diameter, depending on dendron shape. The results correlate well with molecular dynamics simulations. The compounds show relatively high cytotoxicity (IC50 1.2−21.0 μM) associated with micelle formation and inversely related to the size of assembled particles. Depending on their shape, the dendrons show promising results in terms of dendriplex formation and antibacterial activity. In addition to simple amphiphilic dendrons, a fluorescently labeled analogue was also prepared and utilized as an additive visualizingnthe dendron’s cellular uptake.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomacromolecules

ISSN

1525-7797

e-ISSN

1526-4602

Svazek periodika

25

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

7799-7813

Kód UT WoS článku

001352456100001

EID výsledku v databázi Scopus

2-s2.0-85209256454