Improvement of an unbaffled stirred tank mixing characteristics using variable speed impeller

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985874%3A_____%2F24%3A00585697" target="_blank" >RIV/67985874:_____/24:00585697 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.14311/TPFM.2024.008" target="_blank" >http://dx.doi.org/10.14311/TPFM.2024.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14311/TPFM.2024.008" target="_blank" >10.14311/TPFM.2024.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Improvement of an unbaffled stirred tank mixing characteristics using variable speed impeller

Popis výsledku v původním jazyce

Unbaffled mixing tanks with magnetically driven impellers are increasingly used in biotechnological and pharmaceutical industries, combining the benefits of a closed, sterile environment with easy equipment cleanability. On the other hand, missing internals, such as baffles or cooling coils, have an adverse effect on the equipment mixing characteristics, namely the batchnhomogenization time. In our previous research, we uncovered that the eccentricity and inclination of the impeller – both employed routinely to enhance the mixing characteristics of unbaffled vessels – are not fully effective in the suppression of central vortex formation resulting in the increase in the homogenization time. In this work, we propose a simple solution to counteract the central vortex formation – a periodical variation of impeller rotational speed. This approach destabilizes the central vortex, significantly reducing homogenization time while maintaining the benefits of the original unbaffled setup. This innovation can seamlessly integrate into existing industrial setups, promising efficiency gains for biotech and pharmaceutical production.

Název v anglickém jazyce

Improvement of an unbaffled stirred tank mixing characteristics using variable speed impeller

Popis výsledku anglicky

Unbaffled mixing tanks with magnetically driven impellers are increasingly used in biotechnological and pharmaceutical industries, combining the benefits of a closed, sterile environment with easy equipment cleanability. On the other hand, missing internals, such as baffles or cooling coils, have an adverse effect on the equipment mixing characteristics, namely the batchnhomogenization time. In our previous research, we uncovered that the eccentricity and inclination of the impeller – both employed routinely to enhance the mixing characteristics of unbaffled vessels – are not fully effective in the suppression of central vortex formation resulting in the increase in the homogenization time. In this work, we propose a simple solution to counteract the central vortex formation – a periodical variation of impeller rotational speed. This approach destabilizes the central vortex, significantly reducing homogenization time while maintaining the benefits of the original unbaffled setup. This innovation can seamlessly integrate into existing industrial setups, promising efficiency gains for biotech and pharmaceutical production.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Topical Problems of Fluid Mechanics

ISBN

978-80-87012-88-8

ISSN

2336-5781

e-ISSN

—

Počet stran výsledku

7

Strana od-do

54-60

Název nakladatele

Institute of Thermomechanics AS CR, v. v. i.

Místo vydání

Prague

Místo konání akce

Prague

Datum konání akce

21. 2. 2024

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

001242655400008