Performance of label-free optical biosensors: What is figure of merit (not) telling us?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F22%3A00560103" target="_blank" >RIV/67985882:_____/22:00560103 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.bios.2022.114426" target="_blank" >https://doi.org/10.1016/j.bios.2022.114426</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bios.2022.114426" target="_blank" >10.1016/j.bios.2022.114426</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Performance of label-free optical biosensors: What is figure of merit (not) telling us?

Popis výsledku v původním jazyce

Here we study the analytical performance of label-free optical biosensors with respect to analyte-induced refractive index changes that can be measured by a biosensor (refractive index resolution). We present an analytical model that interrelates the refractive index resolution and the parameters of the optical platform of a biosensor. We demonstrate that the figure of merit (FOM), which has been widely used to design optical platforms of label-free optical biosensors, is not an appropriate metric to guide the design or predict the performance of label-free optical biosensors. Therefore, we propose an extended definition of FOM that addresses its limitations. We confirm the validity of the proposed approach by both numerical simulations and experiments. Finally, we show that the analytical model of the refractive index resolution not only makes it possible to predict the performance of a biosensor but also provides strategies for achieving optimal performance.

Název v anglickém jazyce

Performance of label-free optical biosensors: What is figure of merit (not) telling us?

Popis výsledku anglicky

Here we study the analytical performance of label-free optical biosensors with respect to analyte-induced refractive index changes that can be measured by a biosensor (refractive index resolution). We present an analytical model that interrelates the refractive index resolution and the parameters of the optical platform of a biosensor. We demonstrate that the figure of merit (FOM), which has been widely used to design optical platforms of label-free optical biosensors, is not an appropriate metric to guide the design or predict the performance of label-free optical biosensors. Therefore, we propose an extended definition of FOM that addresses its limitations. We confirm the validity of the proposed approach by both numerical simulations and experiments. Finally, we show that the analytical model of the refractive index resolution not only makes it possible to predict the performance of a biosensor but also provides strategies for achieving optimal performance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10306 - Optics (including laser optics and quantum optics)

Projekt

<a href="/cs/project/GX20-23787X" target="_blank" >GX20-23787X: Nové biofotonické nástroje pro studium buněčných procesů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biosensors and Bioelectronics

ISSN

0956-5663

e-ISSN

1873-4235

Svazek periodika

212

Číslo periodika v rámci svazku

SEP 15

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

114426

Kód UT WoS článku

000833517400003

EID výsledku v databázi Scopus

2-s2.0-85131426220