Plasmonic biosensor based on a gold nanostripe array for detection of microRNA related tonmyelodysplastic syndromes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F21%3A00553141" target="_blank" >RIV/67985882:_____/21:00553141 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.snb.2021.130629" target="_blank" >https://doi.org/10.1016/j.snb.2021.130629</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.snb.2021.130629" target="_blank" >10.1016/j.snb.2021.130629</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plasmonic biosensor based on a gold nanostripe array for detection of microRNA related tonmyelodysplastic syndromes

Popis výsledku v původním jazyce

We present a new optical biosensor based on surface plasmons excited on an array of gold nanostripes via attenuated total reflection. We investigate performance of the biosensor using a theoretical model that considers both optical and mass transport aspects. The analysis of optical aspects employs two different approaches: a complex model incorporating optical characteristics of the nanostructure as well as the noise characteristics of the optical readout system and a simple model based solely on the figure of merit of the nanostructure. The theoretical analysis suggests that the optimized biosensor is able to detect molecular analytes at concentrations lower by a factor of - 10 than conventional surface plasmon resonance biosensors. In order to validate the theoretical model, we characterize the gold nanostripe arrays of different designs in model refractometric and biosensing experiments. We show that the nanoplasmonic sensor exhibits refractive index sensitivity of 1989 nm/RIU and refractive index resolution down to 3.6 x 10-7RIU. In addition, we use the nanoplasmonic biosensor for the detection of a microRNA biomarker of myelodysplastic syndromes (miRNA-125b) and demonstrate that the biosensor can detect miRNA-125b at concentrations down to - 17 pM

Název v anglickém jazyce

Plasmonic biosensor based on a gold nanostripe array for detection of microRNA related tonmyelodysplastic syndromes

Popis výsledku anglicky

We present a new optical biosensor based on surface plasmons excited on an array of gold nanostripes via attenuated total reflection. We investigate performance of the biosensor using a theoretical model that considers both optical and mass transport aspects. The analysis of optical aspects employs two different approaches: a complex model incorporating optical characteristics of the nanostructure as well as the noise characteristics of the optical readout system and a simple model based solely on the figure of merit of the nanostructure. The theoretical analysis suggests that the optimized biosensor is able to detect molecular analytes at concentrations lower by a factor of - 10 than conventional surface plasmon resonance biosensors. In order to validate the theoretical model, we characterize the gold nanostripe arrays of different designs in model refractometric and biosensing experiments. We show that the nanoplasmonic sensor exhibits refractive index sensitivity of 1989 nm/RIU and refractive index resolution down to 3.6 x 10-7RIU. In addition, we use the nanoplasmonic biosensor for the detection of a microRNA biomarker of myelodysplastic syndromes (miRNA-125b) and demonstrate that the biosensor can detect miRNA-125b at concentrations down to - 17 pM

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10306 - Optics (including laser optics and quantum optics)

Projekt

<a href="/cs/project/GX20-23787X" target="_blank" >GX20-23787X: Nové biofotonické nástroje pro studium buněčných procesů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sensors and Actuators B - Chemical

ISSN

0925-4005

e-ISSN

0925-4005

Svazek periodika

347

Číslo periodika v rámci svazku

15 November

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

130629

Kód UT WoS článku

000697414400005

EID výsledku v databázi Scopus

2-s2.0-85113691144