Synthesis of Stable Cerium Oxide Nanoparticles Coated with Phosphonic Acid-Based Functional Polymers
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F23%3A00574760" target="_blank" >RIV/67985882:_____/23:00574760 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62156489:43210/23:43923678 RIV/00216208:11320/23:10475818
Výsledek na webu
<a href="https://doi.org/10.1021/acs.langmuir.3c00576" target="_blank" >https://doi.org/10.1021/acs.langmuir.3c00576</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.langmuir.3c00576" target="_blank" >10.1021/acs.langmuir.3c00576</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Synthesis of Stable Cerium Oxide Nanoparticles Coated with Phosphonic Acid-Based Functional Polymers
Popis výsledku v původním jazyce
Functionalpolymers, such as poly(ethylene glycol) (PEG), terminatedwith a single phosphonic acid, hereafter PEG( ik)-Ph are often applied to coat metal oxide surfaces duringpost-synthesis steps but are not sufficient to stabilize sub-10 nmparticles in protein-rich biofluids. The instability is attributedto the weak binding affinity of post-grafted phosphonic acid groups,resulting in a gradual detachment of the polymers from the surface.Here, we assess these polymers as coating agents using an alternativeroute, namely, the one-step wet-chemical synthesis, where PEG( ik)-Ph is introduced with cerium precursorsduring the synthesis. Characterization of the coated cerium oxidenanoparticles (CNPs) indicates a core-shell structure, wherethe cores are 3 nm cerium oxide and the shell consists of functionalizedPEG polymers in a brush configuration. Results show that CNPs coatedwith PEG(1k)-Ph and PEG(2k)-Ph are of potentialinterest for applications as nanomedicines due to their high Ce(III)content and increased colloidal stability in cell culture media. Wefurther demonstrate that the CNPs in the presence of hydrogen peroxideshow an additional absorbance band in the UV-vis spectrum,which is attributed to Ce-O-2 (2-) peroxo-complexes and could be used in the evaluation of their catalyticactivity for scavenging reactive oxygen species.
Název v anglickém jazyce
Synthesis of Stable Cerium Oxide Nanoparticles Coated with Phosphonic Acid-Based Functional Polymers
Popis výsledku anglicky
Functionalpolymers, such as poly(ethylene glycol) (PEG), terminatedwith a single phosphonic acid, hereafter PEG( ik)-Ph are often applied to coat metal oxide surfaces duringpost-synthesis steps but are not sufficient to stabilize sub-10 nmparticles in protein-rich biofluids. The instability is attributedto the weak binding affinity of post-grafted phosphonic acid groups,resulting in a gradual detachment of the polymers from the surface.Here, we assess these polymers as coating agents using an alternativeroute, namely, the one-step wet-chemical synthesis, where PEG( ik)-Ph is introduced with cerium precursorsduring the synthesis. Characterization of the coated cerium oxidenanoparticles (CNPs) indicates a core-shell structure, wherethe cores are 3 nm cerium oxide and the shell consists of functionalizedPEG polymers in a brush configuration. Results show that CNPs coatedwith PEG(1k)-Ph and PEG(2k)-Ph are of potentialinterest for applications as nanomedicines due to their high Ce(III)content and increased colloidal stability in cell culture media. Wefurther demonstrate that the CNPs in the presence of hydrogen peroxideshow an additional absorbance band in the UV-vis spectrum,which is attributed to Ce-O-2 (2-) peroxo-complexes and could be used in the evaluation of their catalyticactivity for scavenging reactive oxygen species.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10306 - Optics (including laser optics and quantum optics)
Návaznosti výsledku
Projekt
<a href="/cs/project/LM2015057" target="_blank" >LM2015057: Laboratoř fyziky povrchů – Optická dráha pro výzkum materiálů</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Langmuir
ISSN
0743-7463
e-ISSN
—
Svazek periodika
39
Číslo periodika v rámci svazku
23
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
8141-8152
Kód UT WoS článku
001011132500001
EID výsledku v databázi Scopus
2-s2.0-85162258621