Degradation of the mechanical properties of poly-lactide-caprolactone-collagen composite for pulmonary artery banding after implantation into a rat's peritoneum

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F25%3A00618887" target="_blank" >RIV/67985891:_____/25:00618887 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21220/25:00383192 RIV/00669806:_____/25:10496865 RIV/46747885:24510/25:00014260 RIV/00216208:11140/25:10496865

Výsledek na webu

<a href="https://doi.org/10.1016/j.medengphy.2025.104319" target="_blank" >https://doi.org/10.1016/j.medengphy.2025.104319</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.medengphy.2025.104319" target="_blank" >10.1016/j.medengphy.2025.104319</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Degradation of the mechanical properties of poly-lactide-caprolactone-collagen composite for pulmonary artery banding after implantation into a rat's peritoneum

Popis výsledku v původním jazyce

Pulmonary artery banding is a surgical procedure performed when there is a shunt between the left and right ventricle. Its aim is to constrict the lumen of the pulmonary artery by using a band to reduce blood flow to the lungs. In this study, we report the results of investigating the mechanical properties of a composite composed of poly(L-lactide-co-epsilon-caprolactone) layers and a collagen matrix (PLCL-COLL). PLCL layers were obtained by electrospinning, impregnated with collagen solution, and finally cross-linked to increase the stiffness of the material. Bands of PLCL-COLL were implanted into a rat peritoneum and explanted after 1, 3, and 6 months in vivo. The mechanical properties of the material before and after implantation were determined using uniaxial tensile tests. The same was done with samples of strips prepared from GORE-TEX material. By comparing the results of tensile tests before implantation and after explantation, it was found that PLCL-COLL degrades in the rat's body and that it exhibits a mechanical response showing of elastic modulus values that correspond well to arterial biomechanics (elastic modulus measured in the initial linear region of the deformation was found to be: 4.14 MPa f 1.11 MPa, 2.34 MPa f 1.02 MPa, 1.11 MPa f 0.77 MPa, and 0.88 MPa f 0.60 MPa before implantation, and 1, 3, and 6 months after implantation respectively). Similar to the elastic modulus, the strength of the PLCL-COLL composite decreased during in vivo exposure (1.32 f 0.32 MPa, 0.60 f 0.26 MPa, 0.44 f 0.11 MPa, and 0.46 f 0.28 MPa before implantation, and 1, 3, and 6 months after implantation respectively). In our experiments, PLCL-COLL material was always more compliant than GORE-TEX (elastic modulus 34.7 MPa f 2.06 MPa before implantation, and 9.35 MPa f 6.80 MPa after implantation). The results suggest that PLCLCOLL could be a suitable candidate for the development of artery banding tapes, and also for further use in cardiovascular surgery.

Název v anglickém jazyce

Degradation of the mechanical properties of poly-lactide-caprolactone-collagen composite for pulmonary artery banding after implantation into a rat's peritoneum

Popis výsledku anglicky

Pulmonary artery banding is a surgical procedure performed when there is a shunt between the left and right ventricle. Its aim is to constrict the lumen of the pulmonary artery by using a band to reduce blood flow to the lungs. In this study, we report the results of investigating the mechanical properties of a composite composed of poly(L-lactide-co-epsilon-caprolactone) layers and a collagen matrix (PLCL-COLL). PLCL layers were obtained by electrospinning, impregnated with collagen solution, and finally cross-linked to increase the stiffness of the material. Bands of PLCL-COLL were implanted into a rat peritoneum and explanted after 1, 3, and 6 months in vivo. The mechanical properties of the material before and after implantation were determined using uniaxial tensile tests. The same was done with samples of strips prepared from GORE-TEX material. By comparing the results of tensile tests before implantation and after explantation, it was found that PLCL-COLL degrades in the rat's body and that it exhibits a mechanical response showing of elastic modulus values that correspond well to arterial biomechanics (elastic modulus measured in the initial linear region of the deformation was found to be: 4.14 MPa f 1.11 MPa, 2.34 MPa f 1.02 MPa, 1.11 MPa f 0.77 MPa, and 0.88 MPa f 0.60 MPa before implantation, and 1, 3, and 6 months after implantation respectively). Similar to the elastic modulus, the strength of the PLCL-COLL composite decreased during in vivo exposure (1.32 f 0.32 MPa, 0.60 f 0.26 MPa, 0.44 f 0.11 MPa, and 0.46 f 0.28 MPa before implantation, and 1, 3, and 6 months after implantation respectively). In our experiments, PLCL-COLL material was always more compliant than GORE-TEX (elastic modulus 34.7 MPa f 2.06 MPa before implantation, and 9.35 MPa f 6.80 MPa after implantation). The results suggest that PLCLCOLL could be a suitable candidate for the development of artery banding tapes, and also for further use in cardiovascular surgery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical Engineering & Physics

ISSN

1350-4533

e-ISSN

1873-4030

Svazek periodika

138

Číslo periodika v rámci svazku

APR

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

104319

Kód UT WoS článku

001453434500001

EID výsledku v databázi Scopus

2-s2.0-105000227797