Mechanical Response of Explanted Collagen-nanofiber Composites Intended for Pulmonary Artery Banding

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F22%3A00358168" target="_blank" >RIV/68407700:21220/22:00358168 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mechanical Response of Explanted Collagen-nanofiber Composites Intended for Pulmonary Artery Banding

Popis výsledku v původním jazyce

Pulmonary artery banding (PAB) is an intervention used in neonates suffering from certain congenital heart diseases to reduce pulmonary over-circulation. Our project deals with the research and development of a new banding material based on collagen-polycaprolactone (COLL-PCL) and collagen-poly[L-lactide/caprolactone] (COLL-PLCL) composites. The composites are biodegradable and give the advantage of PAB as a one-step procedure. However, the rate of degradation of the composites in a real body environment is unknown but can be determined by means of biomechanical analysis. COLL-PCL and COLL-PLCL materials were prepared by electrospinning, followed by the impregnation of the layers with collagen (type I) dispersion and implanted into the abdominal walls of adult Wistar rats. The composites were explanted after 4 weeks and their mechanical properties were evaluated by means of the uniaxial tensile test. Both COLL-PCL and COLL-PLCL were found to maintain their integrity up to explantation, and the results of the tensile experiments confirmed sufficient ultimate stress (0.51 ± 0.13 MPa).

Název v anglickém jazyce

Mechanical Response of Explanted Collagen-nanofiber Composites Intended for Pulmonary Artery Banding

Popis výsledku anglicky

Pulmonary artery banding (PAB) is an intervention used in neonates suffering from certain congenital heart diseases to reduce pulmonary over-circulation. Our project deals with the research and development of a new banding material based on collagen-polycaprolactone (COLL-PCL) and collagen-poly[L-lactide/caprolactone] (COLL-PLCL) composites. The composites are biodegradable and give the advantage of PAB as a one-step procedure. However, the rate of degradation of the composites in a real body environment is unknown but can be determined by means of biomechanical analysis. COLL-PCL and COLL-PLCL materials were prepared by electrospinning, followed by the impregnation of the layers with collagen (type I) dispersion and implanted into the abdominal walls of adult Wistar rats. The composites were explanted after 4 weeks and their mechanical properties were evaluated by means of the uniaxial tensile test. Both COLL-PCL and COLL-PLCL were found to maintain their integrity up to explantation, and the results of the tensile experiments confirmed sufficient ultimate stress (0.51 ± 0.13 MPa).

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

<a href="/cs/project/NU20-02-00368" target="_blank" >NU20-02-00368: Biomechanicky definované vstřebatelné materiály pro kardiovaskulární chirurgii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

EAN 2021 59th conference on experimental stress analysis

ISBN

978-80-01-06885-4

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

236-239

Název nakladatele

katedra mechaniky

Místo vydání

Praha

Místo konání akce

Litomyšl

Datum konání akce

29. 9. 2021

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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