In Vivo Degradation and Local Tissue Response of Experimental Carp Collagen Membranes: Micro-MRI and Histological Analysis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F25%3A00639545" target="_blank" >RIV/67985891:_____/25:00639545 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/25:10501047 RIV/00216208:11140/25:10501047 RIV/00064165:_____/25:10501047
Výsledek na webu
<a href="https://doi.org/10.1002/bip.70045" target="_blank" >https://doi.org/10.1002/bip.70045</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/bip.70045" target="_blank" >10.1002/bip.70045</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
In Vivo Degradation and Local Tissue Response of Experimental Carp Collagen Membranes: Micro-MRI and Histological Analysis
Popis výsledku v původním jazyce
Collagen membranes are widely used in tissue and bone engineering, including guided bone regeneration (GBR). For effective and uninterrupted bone healing, a GBR membrane must maintain its functionality for an initial critical period of 4 weeks. A novel carp collagen sponge has already shown promise as a wound coating and vascular graft coating, making it a candidate for GBR applications as well. To enhance the mechanical properties and longevity of GBR membranes, we modified the basic carp collagen membrane with combinations of l-lactide, epsilon-caprolactone, d,l-lactide, and glycolide in various molar ratios. While traditional methods rely on histological evaluation to assess the degradation pattern and therefore suitability of GBR membranes ex vivo, this study employed micro-MRI as an innovative, noninvasive approach to monitor the in vivo degradation of carp collagen membrane and its polymer-modified variants. Our findings demonstrated that micro-MRI is a reliable and effective method for visualizing collagen membrane degradation in vivo, up to scaffold disintegration. Among the variants tested, collagen GBR membrane coated with d,l-lactide and glycolide in a 50:50 M ratio emerged as the most suitable for GBR purposes. However, since this study was conducted in the subcutaneous tissue of a rat model, further research is required to determine the behavior of carp collagen GBR membrane variants on bony surfaces.
Název v anglickém jazyce
In Vivo Degradation and Local Tissue Response of Experimental Carp Collagen Membranes: Micro-MRI and Histological Analysis
Popis výsledku anglicky
Collagen membranes are widely used in tissue and bone engineering, including guided bone regeneration (GBR). For effective and uninterrupted bone healing, a GBR membrane must maintain its functionality for an initial critical period of 4 weeks. A novel carp collagen sponge has already shown promise as a wound coating and vascular graft coating, making it a candidate for GBR applications as well. To enhance the mechanical properties and longevity of GBR membranes, we modified the basic carp collagen membrane with combinations of l-lactide, epsilon-caprolactone, d,l-lactide, and glycolide in various molar ratios. While traditional methods rely on histological evaluation to assess the degradation pattern and therefore suitability of GBR membranes ex vivo, this study employed micro-MRI as an innovative, noninvasive approach to monitor the in vivo degradation of carp collagen membrane and its polymer-modified variants. Our findings demonstrated that micro-MRI is a reliable and effective method for visualizing collagen membrane degradation in vivo, up to scaffold disintegration. Among the variants tested, collagen GBR membrane coated with d,l-lactide and glycolide in a 50:50 M ratio emerged as the most suitable for GBR purposes. However, since this study was conducted in the subcutaneous tissue of a rat model, further research is required to determine the behavior of carp collagen GBR membrane variants on bony surfaces.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
20601 - Medical engineering
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Biopolymers
ISSN
0006-3525
e-ISSN
1097-0282
Svazek periodika
16
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
20
Strana od-do
e70045
Kód UT WoS článku
001574387300001
EID výsledku v databázi Scopus
2-s2.0-105013541801